Product Summary

Get more sensitive and precise results with saving at least 1-2h comparing to traditional ELISA Kits. The new developed technology in house will help to accelerate your science research in a more efficient way.

Sensitivity	37.5 pg/mL
Detection Range	62.5-4000 pg/mL
Sample Volume	50 μL
Total Assay Time	1 h 30 min
Reactivity	Human
Specificity	This kit recognizes Human FXN in samples. No significant cross-reactivity or interference between Human FXN and analogues was observed.
Recovery	80%-120%
Sample Type	Serum, plasma and other biological fluids
Detection Method	Colorimetric method, ELISA, Sandwich
Assay Type	Sandwich-ELISA
Size	96T / 48T / 24T / 96T5 / 96T10
Storage	2-8℃
Expiration Date	6 months

Background

Frataxin protein (FXN) is a highly conserved mitochondrial protein. The mature form of Frataxin acts as a persulfide transferred to the scaffold protein ISCU as an activator, as a component of the core iron-sulfur cluster (ISC) assembly complex, and participates in [2Fe-2S] cluster assembly. It accelerates the transfer of sulfur from NFS1 persulfide intermediate to ISCU and small thiols (such as L-cysteine and glutathione), leading to persulfidation of these thiols and ultimately release of sulfide. It binds ferrous ions and is released from FXN after addition of L-cysteine and reduced FDX2 during [2Fe-2S] cluster assembly. The core iron-sulfur cluster (ISC) assembly complex is involved in de novo synthesis of [2Fe-2S] clusters, which is the first step in mitochondrial iron-sulfur protein biogenesis. It may play a role in combating iron-catalyzed oxidative stress through its ability to catalyze oxidation of Fe2+ to Fe3+. It can store large amounts of iron in the form of hydrotalcite mineral through oligomerization. It may function as an iron chaperone, protecting the [4Fe-4S]2+ cluster of apo-enzyme from degradation and promoting enzyme reactivation. It may act as a high-affinity iron-binding partner for FECH, which can both deliver iron to the iron chelatase and mediate the terminal step of mitochondrial heme biosynthesis. Extramitochondrial frataxin regulates the RNA-binding activity of ACO1. It may be involved in cytoplasmic iron-sulfur protein biogenesis. It may contribute to oxidative stress resistance and overall cell survival.

Gene Alias	FXN
Gene ID	2395
Uniport ID	Q16595
Protein Alias	FXN
Research Area	细胞生物学

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Size	Price	Qty
96T	$ 520.00	- +
48T	$ 416.00	- +
24T	$ 150.00	- +
96T*5	Inquire	/
96T*10	Inquire	/

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QuicKey Pro Human FXN (Frataxin) ELISA Kit (E-OSEL-H0081)

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