QuicKey Pro Rat SELE (E-selectin) ELISA Kit (E-OSEL-R0018)

E-selectin, also known as endothelial leukocyte adhesion molecule-1 (ELAM-1)and CD62E, is an inducible adhesion molecule that is expressed on the surfaces ofstimulated vascular endothelial cells and is sometimes involved in cancer cellmetastasis. E-selectin exhibits a complex mosaic structure consisting of a largeextracellular region comprised of a lectin domain, an EGF-like domain, and a shortconsensus repeat (SCR) domain, followed by a transmembrane region and arelatively short (32 aa) cytoplasmic tail. As a member of the LEC-CAM or selectinfamily, E-selectin recognises and binds to sialylated carbohydrates includingmembers of the Lewis X and Lewis A families found on monocytes, granulocytes,and T-lymphocytes. E-selectin supports rolling and stable arrest of leukocytes onactivated vascular endothelium, and furthermore, it was indicated that it can alsotransduce an activating stimulus via the MAPK cascade into the endothelial cellduring leukocyte adhesion. E-selectin regulates adhesive interactions betweencertain blood cells and endothelium. The soluble form of E selectin (sE-selectin) isa marker of endothelial activation, and has a potential role in the pathogenesis ofcardiovascular disease as raised levels have been found in hypertension, diabetesand hyperlipidemia, although its association in established atherosclerosis diseaseand its value as a prognostic factor is more controversial. soluble E-selectin isinversely associated with the muscular component of the left ventricle, therebysuggesting that the lack of such a reparative factor may be associated with cardiacremodeling in end-stage renal disease (ESRD) patients. In addition, this adhesionmolecule appears to be involved in the pathogenesis of atherosclerosis.