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Uncoated Rat OC/BGP (Osteocalcin) ELISA Kit (E-UNEL-R0064)

All Size Price Qty
96T*5 $ 399.00
96T*15 $ 958.00
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For research use only.

Product Summary

The new series of Elabscience® Uncoated ELISA kits contain the basic components required for the ELISA experiments. For customers who have rich experience and can establish their own ELISA system, uncoated kit is an ideal choice to save costs.

Detection Range 31.25-2000 pg/mL
Sample Volume 100 μL
Total Assay Time 24 h
Reacitivity Rat
Specificity This kit recognizes Rat OC/BGP in samples.No significant cross-reactivity or interference between Rat OC/BGP and analogues was observed
Recovery 80%-120%
Sample Type Serum, plasma
Detection Method Colorimetric method, ELISA, Sandwich
Size 96T*5 / 96T*15
Storage -20℃
Expiration Date 12 months
The carboxylated form is one of the main organic components of the bone matrix; which constitutes 1-2% of the total bone protein: it acts as a negative regulator of bone formation and is required to limit bone formation without impairing bone resorption or mineralization. The carboxylated form binds strongly to apatite and calcium.The uncarboxylated form acts as a hormone secreted by osteoblasts; which regulates different cellular processes; such as energy metabolism; male fertility and brain development. Regulates of energy metabolism by acting as a hormone favoring pancreatic beta-cell proliferation; insulin secretion and sensitivity and energy expenditure. Uncarboxylated osteocalcin hormone also promotes testosterone production in the testes: acts as a ligand for G protein-coupled receptor GPRC6A at the surface of Leydig cells; initiating a signaling response that promotes the expression of enzymes required for testosterone synthesis in a CREB-dependent manner. Also acts as a regulator of brain development: osteocalcin hormone crosses the blood-brain barrier and acts as a ligand for GPR158 on neurons; initiating a signaling response that prevents neuronal apoptosis in the hippocampus; favors the synthesis of all monoamine neurotransmitters and inhibits that of gamma-aminobutyric acid (GABA). Osteocalcin also crosses the placenta during pregnancy and maternal osteocalcin is required for fetal brain development.
Uniport ID P04640
Research Area Cancer , Signal Transduction , Stem Cells
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