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Design, synthesis and antitumor activity of a novel FGFR2-selective degrader to overcome resistance of the FGFR2V564F gatekeeper mutation based on a pan-FGFR inhibitor
IF: 6.000
  • Journal: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY(2024)
  • DOI: 10.1016/j.ejmech.2024.116612
  • Products: KATO III [KATO 3] Cells Line, BxPC-3 Cells Line, A2780 Cells Line, NCI-H1975 Cells Line, HCT 116 Cells Line, MDA-MB-231 Cells Line, MCF7 [MCF-7] Cells Line, 22RV1 Cells Line, HuH-7 Cells Line, 293T [HEK-293T] Cells Line, AN3 CA Cells Line, 293 [HEK-293] Cells Line, HL-7702 [L-02; LO2] Cells Line
  • Product Category: Cell Line
Discovery of novel natural-product-derived mutant isocitrate dehydrogenases 1 inhibitors: Structure-based virtual screening, biological evaluation and structure-activity relationship study
IF: 6.000
Synergistic immune augmentation enabled by covalently conjugating TLR4 and NOD2 agonists
IF: 6.000
Discovery of novel 2-substituted 2, 3-dihydroquinazolin-4(1H)-one derivatives as tubulin polymerization inhibitors for anticancer therapy: The in vitro and in vivo biological evaluation
IF: 6.000
  • Journal: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY(2024)
  • DOI: 10.1016/j.ejmech.2024.116766
  • Products: U251 Cells Line, PANC-1 Cells Line, A-375 Cells Line, A549 [A-549] Cells Line, Hep G2 Cells Line
  • Product Category: Cell Line
Identification of naphthalimide-derivatives as novel PBD-targeted polo-like kinase 1 inhibitors with efficacy in drug-resistant lung cancer cells
IF: 6.000
  • Journal: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY(2024)
  • DOI: 10.1016/j.ejmech.2024.116416
  • Products: A549/DDP Cells Line
  • Product Category: Cell Line
Synthesis and identification of a selective FGFR2 degrader with potent antiproliferative effects in gastric cancer
IF: 6.000
Design, synthesis and structure-activity relationships of novel non-ketolides: 9-Oxime clarithromycin featured with seven-to thirteen-atom-length diamine linkers at 3-OH
IF: 6.000
Multimechanism biological profiling of tetrahydro-β-carboline analogues as selective HDAC6 inhibitors for the treatment of Alzheimer's disease
IF: 6.000
  • Journal: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY(2024)
  • DOI: 10.1016/j.ejmech.2024.116624
  • Products: SH-SY5Y [SHSY-5Y] Cells Line
  • Product Category: Cell Line
Antioxidant, Anti-Inflammatory, and Anticancer Activities of Five Citrus Peel Essential Oils
IF: 6.000
Essential Oils from Citrus Peels Promote Calcium Overload-Induced Calcicoptosis in U251 Cells
IF: 6.000
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