Alternate Names	Endoglin,END,Eng
Swissprot	Q63961
References	1. Gougos A and M. Letarte 1988. J. Immunol. 141:1925. 2. Cheifetz S, et al. 1992. J. Bio. Chem. 267:19027. 3. Barbara NP, et al. 1999. J. Bio. Chem. 274:584. 4. Lastres P, et al. 1992. Eur. J. Immunol. 22:393. 5. Duff S, et al. 2003. FASEB J. 17:984. 6. Warrington K, et al. 2005. Anticancer Res. 25:185.

Product Details

Form	Liquid
Clone No.	MJ7/18(See Other Available Formats)
Host	Rat
Isotype	Rat IgG2a, κ
Isotype Control	APC Rat IgG2a, κ Isotype Control[2A3] [Product E-AB-F09832E]
Reactivity	Mouse
Application	FCM (See the Application Description)
Storage Buffer	Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Recommended Use	Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Shipping	Biological ice pack at 4℃
Stability & Storage	Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Conjugation	APC
	APC is designed to be excited by the Red (627-640 nm) laser and detected using an optical filter centered near 660 nm (e.g., a 660/20 nm bandpass filter).

How to select the appropriate detection channel through the spectrogram?

Background

CD105 is a 90 kD homodimeric type I integral membrane glycoprotein, also known as endoglin. It is expressed on endothelial cells (especially on angiogenic endothelial cells) and upregulated by hypoxia, activated monocytes, macrophages, bone marrow stromal cells, and some cytotrophoblasts. CD105 is a receptor for TGF-β1, TGF-β3 and modulates TGF-β signaling by interacting with TGF-β receptors I and/or II. CD105 also binds other growth factors such as actvin A, BMP-2, and BMP-7. CD105 has been show to be a useful marker for identifying proliferating endothelium involved in tumor angiogenesis and can be used for tumor imaging and prognosis, and has therapeutic potential for some solid tumors and other angiogenic diseases.

Protocols & Troubleshootings

Related Protocols	Staining Cell Surface Targets for Flow Cytometry
Troubleshooting	Troubleshooting for Flow Cytometry

Alternative Formats

Product Name	Sizes	Price
FITC Anti-Mouse CD105 Antibody[MJ7/18]	50Tests, 100Tests, 100Tests×2	Check More
PE Anti-Mouse CD105 Antibody[MJ7/18]	50Tests, 100Tests, 100Tests×2	Check More
PE Anti-Mouse CD105 Antibody[MJ7/18]	25μg, 100μg	Check More
APC Anti-Mouse CD105 Antibody[MJ7/18]	25μg, 100μg	Check More

Citations

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