Alternate Names	Macrophage colony-stimulating factor 1 receptor,CSF-1 receptor (EC:2.7.10.1),CSF-1-R,CSF-1R,M-CSF-R,Proto-oncogene c-Fms,CD115,Csf1r,Csfmr,Fms
Swissprot	P09581
References	1. Sudo T, et al. 1995 Oncogene 11:2469. 2. Murayama T, et al. 1999 Circulation 99:1740. 3. Goswami S, et al. 2005 Cancer Res. 65:5278. 4. Yu W, et al. 2008 J. Leuko. Biol. 84:852.

Product Details

Form	Liquid
Clone No.	AFS98(See Other Available Formats)
Host	Rat
Isotype	Rat IgG2a, κ
Isotype Control	APC Rat IgG2a, κ Isotype Control[2A3] [Product E-AB-F09832E]
Reactivity	Mouse
Application	FCM (See the Application Description)
Storage Buffer	Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Recommended Use	Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Shipping	Biological ice pack at 4℃
Stability & Storage	Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Conjugation	APC
	APC is designed to be excited by the Red (627-640 nm) laser and detected using an optical filter centered near 660 nm (e.g., a 660/20 nm bandpass filter).

How to select the appropriate detection channel through the spectrogram?

Background

CSF-1R, also known as CD115 and M-CSFR, is a single-pass type I membrane protein and member of the platelet-derived growth factor receptor family. This c-fms (Fms proto-oncogene) gene product's natural ligands include M-CSF and IL-34. Structural studies of CD115 have described an Ig-like extracellular domain, a transmembrane domain, an intracellular juxtamembrane domain, a split tyrosine kinase domain, and a C-terminal tail receptor. Receptor activation induces homodimerization in addition to phosphorylation and ubiquitination of intracellular residues. CD115 directly influences tissue macrophage and osteoclast differentiation and proliferation. It is expressed on monocytes/macrophages, peritoneal exudate cells, plasmacytoid and conventional dendritic cells, and osteoclasts.

Protocols & Troubleshootings

Related Protocols	Staining Cell Surface Targets for Flow Cytometry
Troubleshooting	Troubleshooting for Flow Cytometry

Alternative Formats

Product Name	Sizes	Price
AF/LE Purified Anti-Mouse CD115/CSF-1R Antibody[AFS98]	50μg, 500μg, 1mg	Check More
Purified Anti-Mouse CD115/CSF-1R Antibody[AFS98]	25μg, 100μg	Check More
PE Anti-Mouse CD115/CSF-1R Antibody[AFS98]	50Tests, 100Tests, 100Tests×2	Check More
PE Anti-Mouse CD115/CSF-1R Antibody[AFS98]	25μg, 100μg	Check More
APC Anti-Mouse CD115/CSF-1R Antibody[AFS98]	25μg, 100μg	Check More

Citations

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