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Rat CASP3(Caspase 3) ELISA Kit

  • Cat.No.:E-EL-R0160

  • Reactivity: Rat

To Purchase E-EL-R0160

Size:
  • 96T
  • 48T
  • 24T
  • 96T*5
  • 96T*10
Price: $609
Qty:

Product Details

Properties

Assay type Sandwich-ELISA
Format 96T/48T
Assay time 3.5h
Detection range 0.31-20 ng/mL
Sensitivity 0.19 ng/mL
Sample type &Sample volume serum, plasma and other biological fluids; 100μL
Specificity This kit recognizes Rat CASP3 in samples. No significant cross-reactivity or interference between Rat CASP3 and analogues was observed.
Reproducibility Both intra-CV and inter-CV are < 10%.
Application This ELISA kit applies to the in vitro quantitative determination of Rat CASP3 concentrations in serum, plasma and other biological fluids.

Test Principle

This ELISA kit uses the Sandwich-ELISA principle. The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to Rat CASP3. Standards or samples are added to the micro ELISA plate wells and combined with the specific antibody. Then a biotinylated detection antibody specific for Rat CASP3 and Avidin-Horseradish Peroxidase (HRP) conjugate are added successively to each micro plate well and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain Rat CASP3, biotinylated detection antibody and Avidin-HRP conjugate will appear blue in color. The enzyme-substrate reaction is terminated by the addition of stop solution and the color turns yellow. The optical density (OD) is measured spectrophotometrically at a wavelength of 450 nm ± 2 nm. The OD value is proportional to the concentration of Rat CASP3. You can calculate the concentration of Rat CASP3 in the samples by comparing the OD of the samples to the standard curve.

Kit components & Storage

An unopened kit can be stored at 2-8℃ for 1 month. If the kit is not supposed to be used within 1 month, store the components separately according to the following conditions once the kit is received.
ItemSpecificationsStorage
Micro ELISA Plate(Dismountable) 96T: 8 wells ×12 strips
48T: 8 wells ×6 strips
-20℃, 6 months
Reference Standard 96T: 2 vials
48T: 1 vial
Concentrated Biotinylated Detection Ab (100×) 96T: 1 vial, 120 μL
48T: 1 vial, 60 μL
Concentrated HRP Conjugate (100×) 96T: 1 vial, 120 μL
48T: 1 vial, 60 μL
-20℃(Protect from light), 6 months
Reference Standard & Sample Diluent 1 vial, 20 mL 2-8°C, 6 months
Biotinylated Detection Ab Diluent 1 vial, 14 mL
HRP Conjugate Diluent 1 vial, 14 mL
Concentrated Wash Buffer (25×) 1 vial, 30 mL
Substrate Reagent 1 vial, 10 mL 2-8℃(Protect from light)
Stop Solution 1 vial, 10 mL 2-8°C
Plate Sealer 5 pieces
Manual 1 copy
Certificate of Analysis 1 copy

Technical Data

Precision

Intra-assay Precision (Precision within an assay): 3 samples with low, mid range and high level Rat CASP3 were tested 20 times on one plate, respectively.
Inter-assay Precision (Precision between assays): 3 samples with low, mid range and high level Rat CASP3 were tested on 3 different plates, 20 replicates in each plate.

  Intra-assay Precision Inter-assay Precision
Sample 1 2 3 1 2 3
n 20 20 20 20 20 20
Mean (ng/mL) 1.09 3.21 9.83 1.05 3.10 9.92
Standard deviation 0.07 0.14 0.54 0.06 0.12 0.49
CV (%) 6.42 4.36 5.49 5.71 3.87 4.94

Recovery

The recovery of Rat CASP3 spiked at three different levels in samples throughout the range of the assay was evaluated in various matrices.

Sample Type Range (%) Average Recovery (%)
Serum(n=8) 96-107 101
EDTA plasma (n=8) 87-102 93
Cell culture media (n=8) 91-101 96

Linearity

Samples were spiked with high concentrations of Rat CASP3 and diluted with Reference Standard & Sample Diluent to produce samples with values within the range of the assay.

Target Information

Database LinksSwissProt:   P55213
SynonymsCPP32, CPP32B, SCA-1, Apoptain, Yama
Research AreaCancer, Cell Biology, Metabolism, Neuroscience

Assay Procedures

elisa assay procedure 1

1. Add 100μL standard or sample to the wells. Incubate for 90 min at 37°C

elisa assay procedure 2

2. Discard the liquid, immediately add 100μL Biotinylated Detection Ab working solution to each well. Incubate for 60 min at 37°C

elisa assay procedure 3

3. Aspirate and wash the plate for 3 times

elisa assay procedure 4

4. Add 100μL HRP conjugate working solution. Incubate for 30 min at 37°C. Aspirate and wash the plate for 5 times

elisa assay procedure 5

5. Add 90μL Substrate Reagent. Incubate for 15 min at 37°C

elisa assay procedure 6

6. Add 50μL Stop Solution

elisa assay procedure 7

7. Read the plate at 450nm immediately. Calculation of the results

Related Products

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 Browse all ancillary reagents for ELISA kits


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Citations

  1. CHEMICO-BIOLOGICAL INTERACTIONS (2021) IF: 5.194
    Plumbagin induces testicular damage via mitochondrial-dependent cell death

    DOI: 10.1016/j.cbi.2021.109582

    PMID: 34302802

    Sample: Testis
  2. ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY (2022) IF: 5.785
    Influence of furan and lead co-exposure at environmentally relevant concentrations on neurobehavioral performance, redox-regulatory system and apoptotic responses in rats

    DOI: 10.1016/j.etap.2022.104011

    Sample: Cerebellum,Cerebrum
  3. Frontiers in Pharmacology (2021) IF: 5.811
    Therapeutic Potentials of Selected Antihypertensive Agents and Their Fixed-Dose Combinations Against Trastuzumab-Mediated Cardiotoxicity

    DOI: 10.3389/fphar.2020.610331

    Sample: Cardiac Tissue
  4. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021) IF: 5.924
    Escitalopram Targets Oxidative Stress, Caspase-3, BDNF and MeCP2 in the Hippocampus and Frontal Cortex of a Rat Model of Depression Induced by Chronic Unpredictable Mild Stress

    DOI: 10.3390/ijms22147483

    PMID: 34299103

    Sample: Hippocampus
  5. Current Research in Toxicology (2022)
    Zn and Se abrogate heavy metal mixture induced ovarian and thyroid oxido-inflammatory effects mediated by activation of NRF2-HMOX-1 in female albino rats

    DOI: 10.1016/j.crtox.2022.100098

    Sample: Ovarian,Thyroid,Thyroid Cell
  6. Toxicology Reports (2019)
    Manganese suppresses oxidative stress, inflammation and caspase-3 activation in rats exposed to chlorpyrifos

    DOI: 10.1016/j.toxrep.2019.02.007

    PMID: 30859069

    Sample: Tissue Homogenate
  7. Turkish Journal of Biochemistry-Turk Biyokimya Dergisi (2020) IF: 0.373
    Effects of mesenchymal stem cell and amnion membrane transfer on prevention of pericardial adhesions

    DOI: 10.1515/tjb-2019-0309

    Sample: Serum
  8. Veterinary Research Forum (2019) IF: 1.054
    Crocin exerts improving effects on indomethacin-induced small intestinal ulcer by antioxidant, anti-inflammatory and anti-apoptotic mechanisms

    DOI: 10.30466/vrf.2018.93512.2256

    Sample: Small Intestine Tissue
  9. CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY (2017) IF: 1.822
    Taurine reverses sodium fluoride-mediated increase in inflammation, caspase-3 activity, and oxidative damage along the brain–pituitary–gonadal axis in male rats

    DOI: 10.1139/cjpp-2016-0641

    Sample: Tissue Homogenate
  10. DRUG AND CHEMICAL TOXICOLOGY (2019) IF: 1.946
    Behavioral, histopathological, and biochemical evaluations on the effects of cinnamaldehyde, naloxone, and their combination in morphine-induced cerebellar toxicity

    DOI: 10.1080/01480545.2019.1681446

    PMID: 31656103

    Sample: Tissue Homogenate
  11. NEUROSCIENCE LETTERS (2018) IF: 2.159
    Rutin attenuates neurobehavioral deficits, oxidative stress, neuro-inflammation and apoptosis in fluoride treated rats

    DOI: 10.1016/j.neulet.2018.06.023

    Sample: Tissue Homogenate
  12. HUMAN & EXPERIMENTAL TOXICOLOGY (2019) IF: 2.171
    Hepatorenal protective effects of protocatechuic acid in rats administered with anticancer drug methotrexate:

    DOI: 10.1177/0960327119871095

    Sample: Hepatic And Renal
  13. TOXICOLOGY MECHANISMS AND METHODS (2019) IF: 2.276
    Zinc abrogates anticancer drug tamoxifen-induced hepatotoxicity by suppressing redox imbalance, NO/iNOS/NF-ĸB signaling, and caspase-3-dependent apoptosis in female rats

    DOI: 10.1080/15376516.2019.1669243

    Sample: Liver
  14. TOXICOLOGY MECHANISMS AND METHODS (2020) IF: 2.295
    Comparative effects of galactose-induced aging on mitochondrial permeability transition in rat liver and testis

    DOI: 10.1080/15376516.2020.1755921

    Sample: Liver
  15. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2017) IF: 2.341
    SIRT1 exerts neuroprotective effects by attenuating cerebral ischemia/reperfusion-induced injury via targeting p53/microRNA-22

    DOI: 10.3892/ijmm.2016.2806

    Sample: Tissue Homogenate
  16. Metabolic Syndrome and Related Disorders (2022) IF: 2.363
    Naringenin Prevents Inflammation, Apoptosis, and DNA Damage in Potassium Oxonate-Induced Hyperuricemia in Rat Liver Tissue: Roles of Cytochrome C, NF-κB, Caspase-3, and 8-Hydroxydeoxyguanosine

    DOI: 10.1089/met.2022.0028

    PMID: 35796694

    Sample: Liver Tissue
  17. BMC Pharmacology & Toxicology (2022) IF: 2.605
    Accidental lead in contaminated pipe-borne water and dietary furan intake perturbs rats’ hepatorenal function altering oxidative, inflammatory, and apoptotic balance

    DOI: 10.1186/s40360-022-00615-0

    Sample: Hepatic,Renal
  18. CHEMICO-BIOLOGICAL INTERACTIONS (2016) IF: 2.618
    Chemoprotective role of quercetin in manganese-induced toxicity along the brain-pituitary-testicular axis in rats

    DOI: 10.1016/j.cbi.2016.12.019

    Sample: Tissue Homogenate
  19. JOURNAL OF FOOD BIOCHEMISTRY (2021) IF: 2.72
    Chlorogenic acid co-administration abates tamoxifen-mediated reproductive toxicities in male rats: An experimental approach

    DOI: 10.1111/jfbc.13615

    PMID: 33491243

    Sample: Tissue Homogenate
  20. FUNDAMENTAL & CLINICAL PHARMACOLOGY (2022) IF: 2.747
    The protective effect of 3-indolepropanoic acid on aflatoxin B1-induced systemic perturbation of the liver and kidney function in rats

    DOI: 10.1111/fcp.12842

    PMID: 36214208

    Sample: Liver,Kidney
  21. FUNDAMENTAL & CLINICAL PHARMACOLOGY (2021) IF: 2.748
    Roflumilast improves resolution of sepsis-induced acute kidney injury by retarding late phase renal interstitial immune cells infiltration and leakage in urinary sediments

    DOI: 10.1111/fcp.12711

    PMID: 34212425

    Sample: Renal
  22. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR (2019) IF: 2.773
    Co-treatment of piracetam with risperidone rescued extinction deficits in experimental paradigms of post-traumatic stress disorder by restoring the physiological alterations in cortex and hippocampus

    DOI: 10.1016/j.pbb.2019.172763

    Sample: Plasma
  23. HUMAN & EXPERIMENTAL TOXICOLOGY (2021) IF: 2.903
    Luteolin attenuates doxorubicin-induced derangements of liver and kidney by reducing oxidative and inflammatory stress to suppress apoptosis:

    DOI: 10.1177/09603271211006171

    Sample: Tissue Homogenate
  24. NEUROSCIENCE RESEARCH (2023) IF: 2.904
    Neuroprotection by trans-resveratrol in rats with N-methyl-D-aspartate (NMDA)–induced retinal injury: insights into the role of adenosine A1 receptors

    DOI: 10.1016/j.neures.2023.02.004

    Sample: Retinal
  25. Molecular Medicine Reports (2016) IF: 2.952
    Astaxanthin reduces type 2 diabetic‑associated cognitive decline in rats via activation of PI3K/Akt and attenuation of oxidative stress

    DOI: 10.3892/mmr.2015.4615

    Sample: Tissue Homogenate
  26. JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY (2019) IF: 2.965
    Fluoride and diethylnitrosamine coexposure enhances oxido‐inflammatory responses and caspase‐3 activation in liver and kidney of adult rats

    DOI: 10.1002/jbt.22327

    Sample: Serum
  27. TOXICON (2022) IF: 3.033
    Caffeic acid protects against DNA damage, oxidative and inflammatory mediated toxicities, and upregulated caspases activation in the hepatorenal system of rats treated with aflatoxin B1

    DOI: 10.1016/j.toxicon.2021.12.021

    PMID: 34995555

    Sample: Liver,Kidney
  28. TOXICON (2022) IF: 3.035
    Co-exposure to aflatoxin B1 and therapeutic coartem worsens hepatic and renal function through enhanced oxido-inflammatory responses and apoptosis in rats

    DOI: 10.1016/j.toxicon.2022.106988

    Sample: Liver,Kidney
  29. ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY (2019) IF: 3.061
    Neurobehavioural and biochemical responses associated with exposure to binary waterborne mixtures of zinc and nickel in rats

    DOI: 10.1016/j.etap.2019.103294

    Sample: Cerebellum,Cerebrum,Liver
  30. CHEMICO-BIOLOGICAL INTERACTIONS (2017) IF: 3.143
    Protective properties of 6-gingerol-rich fraction from Zingiber officinale (Ginger) on chlorpyrifos-induced oxidative damage and inflammation in the brain, ovary and uterus of rats

    DOI: 10.1016/j.cbi.2017.03.017

    Sample: Tissue Homogenate
  31. REPRODUCTIVE TOXICOLOGY (2022) IF: 3.143
    Codeine alters female reproductive function by targeting ovarian steroidogenesis and folliculogenesis via the induction of oxidative stress, inflammation, and apoptosis

    DOI: 10.1016/j.reprotox.2022.02.001

    PMID: 35158039

    Sample: Ovarian
  32. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2022) IF: 3.148
    Neuroprotection by Trans-Resveratrol in Rats With Intracerebral Hemorrhage: Insights into the Role of Adenosine A1 Receptors

    DOI: 10.1093/jnen/nlac047

    PMID: 35799401

    Sample: Brain
  33. EUROPEAN JOURNAL OF PHARMACOLOGY (2019) IF: 3.17
    Dietary protocatechuic acid abrogates male reproductive dysfunction in streptozotocin-induced diabetic rats via suppression of oxidative damage, inflammation and caspase-3 activity

    DOI: 10.1016/j.ejphar.2019.01.033

    PMID: 30690002

    Sample: Tissue Homogenate
  34. Cardiovascular Toxicology (2021) IF: 3.239
    Wnt/β-Catenin Antagonist Pyrvinium Exerts Cardioprotective Effects in Polymicrobial Sepsis Model by Attenuating Calcium Dyshomeostasis and Mitochondrial Dysfunction

    DOI: 10.1007/s12012-021-09643-4

    PMID: 33723718

    Sample: Tissue Homogenate(Cardiac)
  35. Cardiovascular Toxicology (2022) IF: 3.239
    Upregulation of Uric Acid Production and Caspase 3 Signalling Mediates Rohypnol-Induced Cardiorenal Damage

    DOI: 10.1007/s12012-022-09723-z

    PMID: 35103933

    Sample: Cardiac,Renal
  36. HUMAN & EXPERIMENTAL TOXICOLOGY (2023) IF: 3.247
    The IL-6/HO-1/STAT3 signaling pathway is implicated in the amelioration of acetaminophen-induced hepatic toxicity: A neonatal rat model

    DOI: 10.1177/09603271231151376

    Sample: Hepatic
  37. NEUROTOXICOLOGY (2019) IF: 3.263
    Neuroprotective mechanisms of selenium against arsenic-induced behavioral impairments in rats

    DOI: 10.1016/j.neuro.2019.10.009

    PMID: 31678059

    Sample: Tissue Homogenate
  38. TOXICOLOGY AND APPLIED PHARMACOLOGY (2020) IF: 3.347
    Co-administration of Luteolin mitigated toxicity in rats' lungs associated with doxorubicin treatment

    DOI: 10.1016/j.taap.2020.115380

    PMID: 33358696

    Sample: Tissue Homogenate
  39. INTERNATIONAL IMMUNOPHARMACOLOGY (2019) IF: 3.361
    The ameliorating effect of cannabinoid type 2 receptor activation on brain, lung, liver and heart damage in cecal ligation and puncture-induced sepsis model in rats

    DOI: 10.1016/j.intimp.2019.105978

    PMID: 31767546

    Sample: Tissue Homogenate
  40. LIFE SCIENCES (2019) IF: 3.448
    Safranal, a constituent of saffron, exerts gastro-protective effects against indomethacin-induced gastric ulcer

    DOI: 10.1016/j.lfs.2019.03.054

    PMID: 30914317

    Sample: Tissue Homogenate
  41. BIOMEDICINE & PHARMACOTHERAPY (2018) IF: 3.457
    The effects of safranal, a constitute of saffron, and metformin on spatial learning and memory impairments in type-1 diabetic rats: behavioral and hippocampal histopathological and biochemical evaluations

    DOI: 10.1016/j.biopha.2018.07.165

    PMID: 30092399

    Sample: Tissue Homogenate
  42. BIOMEDICINE & PHARMACOTHERAPY (2018) IF: 3.457
    Protective effects of L-theanine against doxorubicin-induced nephrotoxicity in rats

    DOI: 10.1016/j.biopha.2018.09.171

    Sample: Plasma,Renal Tissues
  43. ACS Omega (2022) IF: 3.512
    Myricetin (3,3′,4′,5,5′,7-Hexahydroxyflavone) Prevents 5-Fluorouracil-Induced Cardiotoxicity

    DOI: 10.1021/acsomega.1c06475

    Sample: Cardiac Tissue
  44. Toxicology Research (2021) IF: 3.524
    Chlorogenic acid abates oxido-inflammatory and apoptotic responses in the liver and kidney of Tamoxifen-treated rats

    DOI: 10.1093/toxres/tfab002

    Sample: Hepatic,Renal
  45. METABOLIC BRAIN DISEASE (2021) IF: 3.584
    Guggulsterone ameliorates ethidium bromide-induced experimental model of multiple sclerosis via restoration of behavioral, molecular, neurochemical and morphological alterations in rat brain

    DOI: 10.1007/s11011-021-00691-x

    PMID: 33635478

    Sample: Tissue Homogenate(Brain)
  46. JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY (2020) IF: 3.606
    Neuroprotective role of gallic acid in aflatoxin B1‐induced behavioral abnormalities in rats

    DOI: 10.1002/jbt.22684

    Sample: Cerebrum Tissue Lysate Supernatant
  47. LIFE SCIENCES (2020) IF: 3.647
    l-theanine alleviates liver and kidney dysfunction in septic rats induced by cecal ligation and puncture

    DOI: 10.1016/j.lfs.2020.117502

    PMID: 32142764

    Sample: Tissue Homogenate
  48. LIFE SCIENCES (2020) IF: 3.647
    Downregulation of redox imbalance and iNOS/NF-ĸB/caspase-3 signalling with zinc supplementation prevents urotoxicity of cyclophosphamide-induced hemorrhagic cystitis in rats

    DOI: 10.1016/j.lfs.2020.118913

    PMID: 33333050

    Sample: Bladder
  49. JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY (2021) IF: 3.652
    Biochemical and histological alterations of doxorubicin-induced neurotoxicity in rats: Protective role of luteolin

    DOI: 10.1002/jbt.22962

    PMID: 34766659

    Sample: Brain
  50. JOURNAL OF FOOD BIOCHEMISTRY (2022) IF: 3.654
    Twelve weeks of treadmill exercise training with green tea extract reduces myocardial oxidative stress and alleviates cardiomyocyte apoptosis in aging rat: The emerging role of BNIP3 and HIF-1α/IGFBP3 pathway

    DOI: 10.1111/jfbc.14397

    PMID: 36069470

    Sample: Heart Tissue
  51. METABOLIC BRAIN DISEASE (2022) IF: 3.655
    Sarcococca saligna ameliorated D-galactose induced neurodegeneration through repression of neurodegenerative and oxidative stress biomarkers

    DOI: 10.1007/s11011-022-01046-w

    PMID: 35881299

    Sample: Brain Tissue
  52. BMC Complementary and Alternative Medicine (2021) IF: 3.659
    Effect of the standard herbal preparation, STW5, treatment on dysbiosis induced by dextran sodium sulfate in experimental colitis

    DOI: 10.1186/s12906-021-03337-8

    PMID: 34103031

    Sample: Colon
  53. NEUROSCIENCE (2023) IF: 3.708
    Essential Trace Elements Prevent the Impairment in the Retention Memory, Cerebral Cortex, and Cerebellum Damage in Male Rats Exposed to Quaternary Metal Mixture by Up-regulation, of Heme Oxygynase-1 and Down-regulation of Nuclear Factor Erythroid 2-relate

    DOI: 10.1016/j.neuroscience.2023.01.002

    PMID: 36646412

    Sample: Cerebral Cortex,Cerebellum
  54. BIOLOGICAL TRACE ELEMENT RESEARCH (2021) IF: 3.738
    Conivaptan and Boric Acid Treatments in Acute Kidney Injury: Is This Combination Effective and Safe?

    DOI: 10.1007/s12011-021-02977-8

    PMID: 34676519

    Sample: Serum
  55. Heliyon (2020) IF: 3.776
    In vivo exposure to codeine induces reproductive toxicity: role of HER2 and p53/Bcl-2 signaling pathway

    DOI: 10.1016/j.heliyon.2020.e05589

    Sample: Testicular
  56. JOURNAL OF KING SAUD UNIVERSITY SCIENCE (2020) IF: 3.819
    The protecting role of Moringa oleifera in cypermethrin-induced mitochondrial dysfunction and apoptotic events in rats brain

    DOI: 10.1016/j.jksus.2020.06.006

    Sample: Tissue Homogenate
  57. FOOD AND CHEMICAL TOXICOLOGY (2018) IF: 3.977
    Protocatechuic acid ameliorates neurobehavioral deficits via suppression of oxidative damage, inflammation, caspase-3 and acetylcholinesterase activities in diabetic rats

    DOI: 10.1016/j.fct.2018.12.040

    PMID: 30597223

    Sample: Tissue Homogenate
  58. NEUROTOXICITY RESEARCH (2023) IF: 3.978
    Restraint Stress Exacerbates Apoptosis in a 6-OHDA Animal Model of Parkinson Disease

    DOI: 10.1007/s12640-022-00630-3

    Sample: Striatal Tissue
  59. Mycotoxin Research (2023) IF: 4.082
    Neurobehavioral and biochemical responses to artemisinin-based drug and aflatoxin B1 co-exposure in rats

    DOI: 10.1007/s12550-023-00474-6

    Sample: Cerebellar,Cerebral
  60. PHYTOTHERAPY RESEARCH (2020) IF: 4.087
    Lavender and coriander essential oils and their main component linalool exert a protective effect against amyloid‐β neurotoxicity

    DOI: 10.1002/ptr.6827

    Sample: Cell Lysate
  61. TOXICOLOGY (2020) IF: 4.099
    Protocatechuic acid modulates reproductive dysfunction linked to furan exposure in rats

    DOI: 10.1016/j.tox.2020.152556

    PMID: 32758512

    Sample: Serum,Tissue Homogenate
  62. ENVIRONMENTAL TOXICOLOGY (2022) IF: 4.119
    Platelet-rich plasma exhibits anti-inflammatory effect and attenuates cardiomyocyte damage by reducing NF-κB and enhancing VEGF expression in isoproterenol induced cardiotoxicity model

    DOI: 10.1002/tox.23456

    PMID: 35014750

    Sample: Cardiac Tissue
  63. SAUDI JOURNAL OF BIOLOGICAL SCIENCES (2021) IF: 4.219
    Neuroprotective efficacy of 4-Hydroxyisoleucine in experimentally induced intracerebral hemorrhage

    DOI: 10.1016/j.sjbs.2021.07.010

    PMID: 34764759

    Sample: Brain
  64. ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH (2022) IF: 4.223
    3-Indolepropionic acid prevented chlorpyrifos-induced hepatorenal toxicities in rats by improving anti-inflammatory, antioxidant, and pro-apoptotic responses and abating DNA damage

    DOI: 10.1007/s11356-022-21075-3

    PMID: 35644820

    Sample: Hepatic,Renal
  65. NEUROTOXICOLOGY (2021) IF: 4.294
    The diuretic amiloride attenuates doxorubicin-induced chemobrain in rats: Behavioral and mechanistic study

    DOI: 10.1016/j.neuro.2021.10.002

    PMID: 34656704

    Sample: Hippocampus
  66. REDOX REPORT (2022) IF: 4.412
    Suppression of glutathione system and upregulation of caspase 3-dependent apoptosis mediate rohypnol-induced gastric injury

    DOI: 10.1080/13510002.2022.2074128

    PMID: 35535549

    Sample: Gastric Tissue
  67. MOLECULES (2022) IF: 4.412
    Guggulsterone Mediated JAK/STAT and PPAR-Gamma Modulation Prevents Neurobehavioral and Neurochemical Abnormalities in Propionic Acid-Induced Experimental Model of Autism

    DOI: 10.3390/molecules27030889

    Sample: Brain,Blood Plasma
  68. Toxics (2022) IF: 4.472
    Quercetin-3-O-β-D-Glucopyranoside-Rich Fraction from Spondias mombin Leaves Halted Responses from Oxidative Stress, Neuroinflammation, Apoptosis, and Lipid Peroxidation in the Brain of Dichlorvos-Treated Wistar Rats.

    DOI: 10.3390/toxics10080477

    Sample: Brain
  69. INFLAMMOPHARMACOLOGY (2021) IF: 4.473
    Neuroprotective effects of roflumilast against quinolinic acid-induced rat model of Huntington’s disease through inhibition of NF-κB mediated neuroinflammatory markers and activation of cAMP/CREB/BDNF signaling pathway

    DOI: 10.1007/s10787-020-00787-3

    Sample: Tissue Homogenate(Brain)
  70. PSYCHOPHARMACOLOGY (2021) IF: 4.53
    Selenium abates manganese–induced striatal and hippocampal toxicity via abrogation of neurobehavioral deficits, biometal accumulation, oxidative stress, inflammation, and caspase-3 activation in rats

    DOI: 10.1007/s00213-021-06010-7

    Sample: Striatum,Hippocampus
  71. PSYCHOPHARMACOLOGY (2021) IF: 4.53
    Effects of catechin on a rodent model of autism spectrum disorder: implications for the role of nitric oxide in neuroinflammatory pathway

    DOI: 10.1007/s00213-021-05941-5

    PMID: 34448020

    Sample: Brain
  72. ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY (2021) IF: 4.86
    Indole-3-propionic acid mitigates chlorpyrifos-mediated neurotoxicity by modulating cholinergic and redox-regulatory systems, inflammatory stress, apoptotic responses and DNA damage in rats

    DOI: 10.1016/j.etap.2021.103786

    PMID: 34915193

    Sample: Brain
  73. MOLECULES (2022) IF: 4.927
    Restoration of Hepatic and Intestinal Integrity by Phyllanthus amarus Is Dependent on Bax/Caspase 3 Modulation in Intestinal Ischemia-/Reperfusion-Induced Injury

    DOI: 10.3390/molecules27165073

    PMID: 36014309

    Sample: Intestinal,Hepatic
  74. MOLECULES (2022) IF: 4.927
    7-Hydroxyflavone Alleviates Myocardial Ischemia/Reperfusion Injury in Rats by Regulating Inflammation

    DOI: 10.3390/molecules27175371

    PMID: 36080137

    Sample: Serum
  75. LIFE SCIENCES (2022) IF: 5.037
    Integration of synthetic and natural derivatives revives the therapeutic potential of temozolomide against glioma- an in vitro and in vivo perspective

    DOI: 10.1016/j.lfs.2022.120609

    PMID: 35526592

    Sample: C6 Cell,U-87 Mg Cell,Ln229 Cell
  76. CHEMOSPHERE (2019) IF: 5.108
    Impact of binary waterborne mixtures of nickel and zinc on hypothalamic-pituitary-testicular axis in rats

    DOI: 10.1016/j.chemosphere.2019.124501

    PMID: 31398612

    Sample: Serum
  77. CHEMICO-BIOLOGICAL INTERACTIONS (2023) IF: 5.168
    Protective effect of eicosapentaenoic acid against estradiol valerate-induced endometrial hyperplasia via modulation of NF-κB/HIF-1α/VEGF signaling pathway in rats

    DOI: 10.1016/j.cbi.2023.110399

    Sample: Uterine Tissue
  78. Pharmaceuticals (2022) IF: 5.215
    Lycopene Modulates Oxidative Stress and Inflammation in Hypercholesterolemic Rats

    DOI: 10.3390/ph15111420

    Sample: Cardiac,Renal
  79. FOOD AND CHEMICAL TOXICOLOGY (2022) IF: 5.572
    Banana peel ameliorated hepato-renal damage and exerted anti-inflammatory and anti-apoptotic effects in metal mixture mediated hepatic nephropathy by activation of Nrf2/ Hmox-1 and inhibition of Nfkb pathway

    DOI: 10.1016/j.fct.2022.113471

    PMID: 36270409

    Sample: Liver,Kidney
  80. REDOX REPORT (2022) IF: 5.696
    Atorvastatin-mediated downregulation of VCAM-1 and XO/UA/caspase 3 signaling averts oxidative damage and apoptosis induced by ovarian ischaemia/reperfusion injury

    DOI: 10.1080/13510002.2022.2129192

    PMID: 36200598

    Sample: Ovarian
  81. ENVIRONMENTAL POLLUTION (2019) IF: 5.714
    Selenium abates reproductive dysfunction via attenuation of biometal accumulation, oxido-inflammatory stress and caspase-3 activation in male rats exposed to arsenic

    DOI: 10.1016/j.envpol.2019.113079

    PMID: 31473390

    Sample: Serum
  82. BIOMEDICINE & PHARMACOTHERAPY (2022) IF: 6.53
    Glutamine prevents upregulation of NF-kB signaling and caspase 3 activation in ischaemia/reperfusion-induced testicular damage: An animal model

    DOI: 10.1016/j.biopha.2022.113056

    PMID: 35658227

    Sample: Testicular Tissue
  83. BIOMEDICINE & PHARMACOTHERAPY (2022) IF: 7.419
    Antioxidant and anti-apoptotic effects of tocotrienol-rich fraction against streptozotocin-induced diabetic retinopathy in rats

    DOI: 10.1016/j.biopha.2022.113533

    PMID: 36076612

    Sample: Retinal
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