Purified Anti-Human CD146 Antibody[P1H12] (AN003230P)
![Purified Anti-Human CD146 Antibody[P1H12] - 1](http://file.elabscience.com/assets/images/loading.png)
For research use only.
Conjugation: Unconjugated
APC Elab Fluor®488 Elab Fluor®647 Elab Fluor®Violet 450 FITC PE PE/Cyanine 5 PE/Cyanine 5.5 PE/Cyanine 7 Unconjugated Show More
| Alternate Names | CD146, cell surface glycoprotein MUC18, MUC18, A32 antigen, CD 146, CD146 antigen, Cell surface glycoprotein P1H12, Gicerin, Melanoma adhesion molecule, Melanoma associated antigen A32, Melanoma associated antigen MUC18, Melanoma associated glycoprotein MUC18, melanoma cell adhesion molecule, Melanoma-associated antigen A32, Melanoma-associated antigen MUC18, MelCAM, MUC 18, S endo 1, S endo 1 endothelial associated antigen, S-endo 1 endothelial-associated antigen, MUC, cell surface glycoprotein MUC, MCAM, CD146, MUC18, cell surface glycoprotein MUC18, S-endo, MCAM, Mel-CAM, Endo-CAM |
| Clone | |
| Verified Samples | Verified Samples in FCM: Hela |
| Dilution | FCM 2 μg/mL(0.5×106-1×106 cells) |
| Background | Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration. |
| Immunogen | Recombinant Human CD146 protein |
| Abbre | CD146 |
| Swissprot | |
| Host | Mouse |
| Reactivity | Human |
| Clonality | Monoclonal |
| Purification Method | >98%, Protein A/G purified |
| Isotype | Mouse IgG1, κ |
| Isotype Control | Purified Mouse IgG1, κ Isotype Control[MOPC-21] |
| Applications |
FCM
|
| Research Areas | Signal Transduction;Cardiovascular Biology;Cancer;Stem Cells;Immunology;Invasion and Metastasis;Cell Adhesion Molecules;Cytoskeleton;CDs;Endothelial Progenitors Markers;Tumor Biomarkers |
| Cellular Localization |
Membrane
|
| Tissue Specificity |
Detected in endothelial cells in vascular tissue throughout the body. May appear at the surface of neural crest cells during their embryonic migration. Appears to be limited to vascular smooth muscle in normal adult tissues.
|
| Concentration |
≥ 1 mg/mL
|
| Conjugation | Unconjugated |
| Storage Buffer | Phosphate-buffered solution, pH 7.2, containing 0.05% non-protein stabilizer. Dialyze to completely remove the stabilizer prior to labeling. |
| Storage | Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles. |
| Expiration Date | 12 months |
| Shipping | Ice bag |
| Cat.No. | Product Name | Clone No. |
|---|---|---|
| E-AB-F14170P | Purified Anti-Human CD146 Antibody[AA98] | AA98 |
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