Product Summary

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Sensitivity	9.38 pg/mL
Detection Range	15.63-1000 pg/mL
Sample Volume	50 μL
Total Assay Time	1 h 30 min
Reactivity	Mouse
Specificity	This kit recognizes Mouse CD48 in samples. No significant cross-reactivity or interference between Mouse CD48 and analogues was observed.
Recovery	80%-120%
Sample Type	Serum, plasma and other biological fluids
Detection Method	Colorimetric method, ELISA, Sandwich
Assay Type	Sandwich-ELISA
Size	96T / 48T / 24T / 96T5 / 96T10
Storage	2-8℃
Expiration Date	6 months

Background

CD48, also known as BLAST-1, BCM-1, and SLAMF2, is a 65 kDa GPI-linked protein in the CD2 family of immunoglobulin superfamily proteins . The mouse CD48 cDNA encodes a 240 amino acid (aa) precursor that includes a 22 aa signal sequence, a 195 aa mature protein that contains one Ig-like V-type domain and one Ig-like C2-type domain, and a 23 aa C-terminal propeptide . A soluble form of CD48 has been detected in the serum of lymphoid leukemia and arthritis patients . Mouse CD48 shares 51% and 68% aa sequence identity with human and rat CD48, respectively. It shares 18%‑26% aa sequence identity with comparable regions of mouse 2B4, BLAME, CD2F-10, CD84, CD229, CRACC, NTB-A, and SLAM. CD48 is expressed on most lineage-committed hematopoietic cells but not on hematopoietic stem cells or multipotent hematopoietic progenitors . Among dendritic cells (DC), CD48 is selectively expressed on circulating myeloid DC and resident bone marrow and thymus DC . CD2, 2B4, and heparan sulfate function as CD48 ligands . CD48 is competent to transduce signals and can also trigger signaling through CD2 or 2B4. CD48-CD2 interactions promote T cell activation and class switching to IgG2a in B cells . High affinity CD48-2B4 interactions can either promote or inhibit NK cell and cytotoxic T cell (CTL) activation . CD48-2B4 ligation does not directly trigger CTL activity but enhances signaling from the T cell receptor . CD48-2B4 mediated inhibition of NK cell activity is distinct from MHC I-restricted mechanisms . CD48 expressed on NK cells is coactivating, whereas CD48 expressed on other cell types inhibits NK cell activation (14). Both CD48 expressing and nonexpressing cells can be targets of NK cell or CTL-mediated lysis

Gene Alias	Cd48
Gene ID	12506
Uniport ID	P18181
Protein Alias	Cd48
Research Area	免疫学

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Size	Price	Qty
96T	$ 520.00	- +
48T	$ 416.00	- +
24T	$ 150.00	- +
96T*5	Inquire	/
96T*10	Inquire	/

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QuicKey Pro Mouse CD48 (Cluster Of Differentiation 48) ELISA Kit (E-OSEL-M0027)

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