PE/Cyanine5 Anti-Human HLA-DQ Antibody[1a3] (AN00421G)
![PE/Cyanine5 Anti-Human HLA-DQ Antibody[1a3] - 1](http://file.elabscience.com/assets/images/loading.png)
For research use only.
Conjugation: PE/Cyanine 5
APC Elab Fluor®488 Elab Fluor®647 Elab Fluor®Violet 450 FITC PE PE/Cyanine 5 PE/Cyanine 5.5 PerCP/Cyanine 5.5 Unconjugated Show More
| Isotype | Mouse IgG2a, κ |
| Host | Mouse |
| Reactivity | Human |
| Applications | FCM |
| Clonality | Monoclonal |
| Abbre | HLA-DQ |
| Synonyms | MHC class II DQ monomorphic antigen, MHC II |
| Swissprot | |
| Cellular Localization | Membrane |
| Concentration | 5 μL/Test |
| Buffer | Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer. |
| Clone No. | 1a3 |
| Conjugation | PE/Cyanine 5 |
| Storage | This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze. |
| Shipping | Ice bag |
| background | HLA-DQ is also known as MHC class II DQ monomorphic antigen. The major histocompatibility complex is composed of two heterodimeric glycoproteins (α and β chains) with apparent molecular weights of 27 and 32 kD. In contrast to other MHC class II molecules, both polypeptide chains of HLA-DQ are polymorphic, with the α chain showing an extremely high degree of polymorphism. HLA-DQ is expressed on B cells in the peripheral blood, and weakly expressed on activated T cells and some monocytes. HLA-DQ is absent on hematopoietic progenitors, resting T cells, erythrocytes, and platelets. HLA-DQ is expressed after HLA-DR and HLA-DP in hematopoietic development. HLA-DQ presents peptide fragments mainly from degraded intravesicular and extracellular proteins to CD4+ T lymphocytes. Specific alleles of HLA-DQ have been linked to the pathogenesis of several autoimmune diseases (including diabetes), both as a susceptibility and resistance factor depending on the particular polymorphism. |
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