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OXA1L deficiency causes mitochondrial myopathy via reactive oxygen species regulated nuclear factor kappa B signalling pathway
IF: 6.800
Design, Synthesis, and Biological Evaluation of Macrocyclic 2-Amino-4-phenylaminopyrimidine Derivatives as Potent JAK2 Inhibitors
IF: 6.800
Discovery of a Proteolysis-Targeting Chimera Degrader of JAK2 as a Potential Therapeutic Agent for JAK2-Mediated Myeloproliferative Neoplasms
IF: 6.800
Tailoring Escherichia coli for high-yield production of O-acetyl-L-homoserine through multi-node metabolic regulation
IF: 6.800
Platinum(IV) Prodrug with a Docosahexaenoic Acid Ligand Preferentially Accumulates in Drug-Resistant Cells and Triggers Ferroptosis to Overcome Drug Resistance
IF: 6.800
  • Journal: JOURNAL OF MEDICINAL CHEMISTRY(2025)
  • DOI: 10.1021/acs.jmedchem.5c00086
  • Products: 3T3-L1 Cells Line, B16-F10 Cells Line, AGS/DDP Cells Line, HL-7702 [L-02; LO2] Cells Line, A549/DDP Cells Line, MCF-7/ADM Cells Line, A549 [A-549] Cells Line, Panc02 Cells Line, MCF7 [MCF-7] Cells Line, MDA-MB-231 Cells Line, HCT 116 Cells Line, AGS Cells Line
  • Product Category: Cell Line
MMAE-Based Peptide–Drug Conjugates Targeting GPC3 for Precision Chemoradiotherapy in Hepatocellular Carcinoma
IF: 6.800
  • Journal: JOURNAL OF MEDICINAL CHEMISTRY(2025)
  • DOI: 10.1021/acs.jmedchem.5c00847
  • Products: Hela Cells Line, Hep 3B2.1-7 Cells Line, HuH-7 Cells Line
  • Product Category: Cell Line
3-Hydroxyquinolin-2-Ones Act as Dual Inhibitors of Ferroptosis and Monoamine Oxidase B: Reducing Alzheimer’s Disease-Related Amyloid Precursor Protein and Hyperphosphorylated Tau In Vivo
IF: 6.800
  • Journal: JOURNAL OF MEDICINAL CHEMISTRY(2025)
  • DOI: 10.1021/acs.jmedchem.5c00502
  • Products: HT22 Cells Line, PC-12 (Undifferentiated) Cells Line
  • Product Category: Cell Line
Elevation of ISG15 promotes diabetic kidney disease by modulating renal tubular epithelial cell pyroptosis
IF: 6.800
  • Journal: Clinical and Translational Medicine(2025)
  • DOI: 10.1002/ctm2.70337
  • Products: Mouse Glomerular Mesangial Cells, Mouse Glomerular Endothelial Cells, Mouse Renal Podocyte Cells
  • Product Category: Primary Cell
Extracellular HSP90-Facilitated Degradation of Extracellular and Membrane Proteins by Bifunctional Small Molecules
IF: 6.800
  • Journal: JOURNAL OF MEDICINAL CHEMISTRY(2025)
  • DOI: 10.1021/acs.jmedchem.5c00379
  • Products: Human Umbilical Vein Endothelial Cells, B16-F10 Cells Line, HULEC-5a Cells Line
  • Product Category: Cell Line,Primary Cell
Design, Synthesis, and Anti-ischemic Stroke Activity Evaluation of Novel GSNOR Inhibitors
IF: 6.800
  • Journal: JOURNAL OF MEDICINAL CHEMISTRY(2025)
  • DOI: 10.1021/acs.jmedchem.5c00857
  • Products: SH-SY5Y [SHSY-5Y] Cells Line
  • Product Category: Cell Line
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