Synonyms:ACL,Acly,ACLY,ATP citrate (pro-S) lyase,ATP citrate lyase,ATP citrate synthase,ATP-citrate (pro-S-)-lyase,ATP-citrate synthase,ATPcitrate synthase,ATPCL,Citrate cleavage enzyme,CLATP,OTTHUMP00000164773
|Synonyms||ACL,Acly,ACLY,ATP citrate (pro-S) lyase,ATP citrate lyase,ATP citrate synthase,ATP-citrate (pro-S-)-lyase,ATP-citrate synthase,ATPcitrate synthase,ATPCL,Citrate cleavage enzyme,CLATP,OTTHUMP00000164773|
|Immunogen||Synthesized peptide derived from human ATP-citrate synthase around the non-phosphorylation site of Ser455.|
|Recommended dilution||WB 1:500-1:2000, IF 1:100-1:300, ELISA 1:10000|
|Storage instructions||Store at -20℃. Avoid freeze / thaw cycles.|
|Storage buffer||PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4|
|Background||ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Two transcript variants encoding distinct isoforms have been identified for this gene.|
Western Blot analysis of COS-7 cells using ACLY Polyclonal Antibody at dilution of 1:1000.