Current Position:Home>>Antibodies>>FCM Antibodies>> AF/LE Purified Anti-Human CD279/PD-1 Antibody[EH12.2H7] E-AB-F12290
|Alternate Names||PDCD1,PD1,Protein PD-1,hPD-1|
1. Pollok KE, et al. 1995. Eur. J. Immunol. 25:488.
2. DeBenedette MA, et al. 1997. J. Immunol. 158:551.
3. Pollok KE, et al. 1993. J. Immunol. 150:771.
4. Pollok KE, et al. 1994. Eur. J. Immunol. 24:367.
5. Goodwin RG, et al. 1993. Eur. J. Immunol. 23:2631.
|Clone No.||EH12.2H7(See Other Available Formats)|
|Isotype||Mouse IgG1, κ|
|Isotype Control||AF/LE Purified Mouse IgG1, κ Isotype Control[MOPC-21] [Product E-AB-F097930]|
|Application||FCM, IHC,Block (See the Application Description)|
|Storage Buffer||0.2 μm filtered in PBS, pH7.2. Azide Free (AF)/Low Endotoxin (LE): Contains no stabilizers or preservatives. Endotoxin level is < 2 EU/mg (Determined by LAL gel clotting assay.|
|Recommended Use||Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 2.0 g per 106 cells in 100 μL volume or 100 μL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.|
|Shipping||Biological ice pack at 4℃|
|Stability & Storage||Keep as concentrated solution.
Store at 2~8℃. Do not freeze.
Centrifuge before opening to ensure complete recovery of vial contents.
This product is guaranteed up to one year from purchase.
|Conjugation||None (Purified antibody/Azide Free/Low endotoxin)|
|Programmed cell death 1 (PD-1), also known as CD279, is a 55 kD member of the immunoglobulin superfamily. CD279 contains the immunoreceptor tyrosine-based inhibitory motif (ITIM) in the cytoplasmic region and plays a key role in peripheral tolerance and autoimmune disease. CD279 is expressed predominantly on activated T cells, B cells, and myeloid cells. PD-L1 and PD-L2 are ligands of CD279 (PD-1) and are members of the B7 gene family. Evidence suggests overlapping functions for these two PD-1 ligands and their constitutive expression on some normal tissues and upregulation on activated antigen-presenting cells. Interaction of CD279 ligands results in inhibition of T cell proliferation and cytokine secretion.|
|Related Protocols||Staining Cell Surface Targets for Flow Cytometry|
|E-AB-F12290||AF/LE Purified Anti-Human CD279/PD-1 Antibody[EH12.2H7] E-AB-F12290||50 μg, 500 μg, 1 mg|
|E-AB-F1229A||Purified Anti-Human CD279/PD-1 Antibody[EH12.2H7] E-AB-F1229A||25 μg, 100 μg|
|E-AB-F1229D||PE Anti-Human CD279/PD-1 Antibody[EH12.2H7] E-AB-F1229D||20 Tests, 50 Tests, 100 Tests, 200 Tests|
|E-AB-F1229E||APC Anti-Human CD279/PD-1 Antibody[EH12.2H7] E-AB-F1229E||20 Tests, 50 Tests, 100 Tests, 200 Tests|