Anti-Mouse FOXP3 Monoclonal Antibody (PE conjugated)

  • Flow cytometry antibody-Elabscience
  • Flow cytometry antibody-Elabscience
  • Flow cytometry antibody-Elabscience
    • Flow cytometry antibody-Elabscience
    • Flow cytometry antibody-Elabscience
    • Flow cytometry antibody-Elabscience
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    • Flow cytometry antibody-Elabscience
    • Flow cytometry antibody-Elabscience
    • Flow cytometry antibody-Elabscience
    • Flow cytometry antibody-Elabscience
    • Flow cytometry antibody-Elabscience
    • Flow cytometry antibody-Elabscience

      Catalog number:E-AB-2292

      Synonyms:AIID,DIETER,Forkhead box P3,Forkhead box protein P3,FOXP3,FOXP3,FOXP3delta7,Immune dysregulation polyendocrinopathy enteropathy X linked,Immunodeficiency polyendocrinopathy enteropathy X linked,IPEX,JM2,MGC141961,MGC141963,OTTHUMP00000025832,OTTHUMP00000025833,OTTHUMP00000226737,PIDX,Scurfin,XPID

      Size:
      • 25μg
      • 100μg
      Qty:
      - +
      Price: $393

      Host: Rat

      Reactivity: M

      Applications: FCM

      Lead Time: 7~10 daysWelcome to order from local distributors.

      Add to cart Compare Bulk request Manual

      Overview

      Synonyms AIID,DIETER,Forkhead box P3,Forkhead box protein P3,FOXP3,FOXP3,FOXP3delta7,Immune dysregulation polyendocrinopathy enteropathy X linked,Immunodeficiency polyendocrinopathy enteropathy X linked,IPEX,JM2,MGC141961,MGC141963,OTTHUMP00000025832,OTTHUMP00000025833,OTTHUMP00000226737,PIDX,Scurfin,XPID
      Swissprot Q99JB6
      Source Rat
      Reactivity Mouse
      Application FCM

      Properties

      Clone No MF-23
      Isotype Rat IgG2b
      Conjugation PE
      Storage instructions Keep as concentrated solution. Store at 4°C and protected from prolonged exposure to light. Do not freeze.
      Storage buffer PBS with 0.09% NaN3, 0.2% BSA, PH7.2
      Background FOXP3 is a 50-55 kD transcription factor, also known as Forkhead box protein P3, Scurfin, JM2, or IPEX. It is proposed to be a master regulatory gene and more specific marker of T regulatory cells than most cell surface markers (such as CD4 and CD25). Transduced expression of FOXP3 in CD4+/CD25- cells has been shown to induce GITR, CD103, and CTLA4 and impart a T regulatory cell phenotype. FOXP3 is mutated in X-linked autoimmunity-allergic dysregulation syndrome (XLAAD or IPEX) in humans and in "scurfy" mice. Overexpression of FOXP3 has been shown to lead to a hypoactive immune state suggesting that this transcriptional factor is a central regulator of T cell activity. In human, unlike in mouse, two isoforms of FOXP3 have been reported: one (FOXP3) corresponding to the canonical full-length sequence; the other (FOXP3 δ2) lacking exon 2. The 150D monoclonal antibody reacts with human, mouse and rat FOXP3. The 150D antibody recognizes FOXP3 epitope encoded by exon 2.

      Fluorochrome

      Phycoerythrin (PE) is a red protein-pigment complex from the light-harvesting phycobiliprotein family, present in red algae and cryptophytes, accessory to the main chlorophyll pigments responsible for photosynthesis. It is a 240-KDa protein.

      Images

      C57BL/6 splenocytes surface stained with APC anti-mouse CD4 and PE anti-mouse FOXP3.

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