Current Position:Home>>Antibodies>>Flow Cytometry Antibody>> Anti-Mouse FOXP3 Monoclonal Antibody (PE conjugated)
Synonyms:AIID,DIETER,Forkhead box P3,Forkhead box protein P3,FOXP3,FOXP3,FOXP3delta7,Immune dysregulation polyendocrinopathy enteropathy X linked,Immunodeficiency polyendocrinopathy enteropathy X linked,IPEX,JM2,MGC141961,MGC141963,OTTHUMP00000025832,OTTHUMP00000025833,OTTHUMP00000226737,PIDX,Scurfin,XPID
|Synonyms||AIID,DIETER,Forkhead box P3,Forkhead box protein P3,FOXP3,FOXP3,FOXP3delta7,Immune dysregulation polyendocrinopathy enteropathy X linked,Immunodeficiency polyendocrinopathy enteropathy X linked,IPEX,JM2,MGC141961,MGC141963,OTTHUMP00000025832,OTTHUMP00000025833,OTTHUMP00000226737,PIDX,Scurfin,XPID|
|Storage instructions||Keep as concentrated solution. Store at 4°C and protected from prolonged exposure to light. Do not freeze.|
|Storage buffer||PBS with 0.09% NaN3, 0.2% BSA, PH7.2|
|Background||FOXP3 is a 50-55 kD transcription factor, also known as Forkhead box protein P3, Scurfin, JM2, or IPEX. It is proposed to be a master regulatory gene and more specific marker of T regulatory cells than most cell surface markers (such as CD4 and CD25). Transduced expression of FOXP3 in CD4+/CD25- cells has been shown to induce GITR, CD103, and CTLA4 and impart a T regulatory cell phenotype. FOXP3 is mutated in X-linked autoimmunity-allergic dysregulation syndrome (XLAAD or IPEX) in humans and in "scurfy" mice. Overexpression of FOXP3 has been shown to lead to a hypoactive immune state suggesting that this transcriptional factor is a central regulator of T cell activity. In human, unlike in mouse, two isoforms of FOXP3 have been reported: one (FOXP3) corresponding to the canonical full-length sequence; the other (FOXP3 δ2) lacking exon 2. The 150D monoclonal antibody reacts with human, mouse and rat FOXP3. The 150D antibody recognizes FOXP3 epitope encoded by exon 2.|
Phycoerythrin (PE) is a red protein-pigment complex from the light-harvesting phycobiliprotein family, present in red algae and cryptophytes, accessory to the main chlorophyll pigments responsible for photosynthesis. It is a 240-KDa protein.
C57BL/6 splenocytes surface stained with APC anti-mouse CD4 and PE anti-mouse FOXP3.