AQP2 Polyclonal Antibody

Uniprot: P41181
  • polyclonal antibody-Elabscience
  • polyclonal antibody-Elabscience
  • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
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    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience

      Catalog number:E-AB-30540

      Synonyms:ADH water channel,AQP 2,AQP CD,AQP-2,AQP-CD,AQP2,AQP2,AQPCD,Aquaporin 2 collecting duct,Aquaporin CD,Aquaporin-2,Aquaporin-CD,Aquaporin2,Aquaporine 2,Collecting duct water channel protein,MGC34501,Water channel aquaporin 2,Water channel protein for renal collecting duct,WCH CD,WCH-CD,WCHCD

      Size:
      • 20 μL
      • 60 μL
      • 120 μL
      • 200 μL
      Qty:
      - +
      Price: $69

      Host: Rabbit

      Reactivity: H,M,R,Mk

      Applications: WB,IHC-p,IF,ELISA

      Lead Time: 2 daysWelcome to order from local distributors.

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      Overview

      Synonyms ADH water channel,AQP 2,AQP CD,AQP-2,AQP-CD,AQP2,AQP2,AQPCD,Aquaporin 2 collecting duct,Aquaporin CD,Aquaporin-2,Aquaporin-CD,Aquaporin2,Aquaporine 2,Collecting duct water channel protein,MGC34501,Water channel aquaporin 2,Water channel protein for renal collecting duct,WCH CD,WCH-CD,WCHCD
      Swissprot P41181
      Source Rabbit
      Reactivity Human,Mouse,Rat,Monkey
      Immunogen Synthesized peptide derived from human AQP2 around the non-phosphorylation site of Ser256.
      Application WB,IHC-p,IF,ELISA
      Recommended dilution WB 1:500-1:2000, IHC 1:100-1:300, IF 1:200-1:1000, ELISA 1:10000
      Concentration 1mg/mL
      Clonality Polyclonal

      Properties

      Cellular localization Apical cell membrane. Basolateral cell membrane. Cytoplasmic vesicle membrane. Golgi apparatus, trans-Golgi network membrane. Shuttles from vesicles to the apical membrane. Vasopressin-regulated phosphorylation is required for translocation to the apical cell membrane. PLEKHA8/FAPP2 is required to transport AQP2 from the TGN to sites where AQP2 is phosphorylated.
      Tissue specificity Expressed in renal collecting tubules.
      Isotype IgG
      Purification Affinity purification
      Conjugation Unconjugated
      Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
      Storage buffer PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
      Background The basic job of aquaporin 2 is to reabsorb water from the urine while its being removed from the blood by the kidney. Aquaporin 2 is in kidney epithelial cells and usually lies dormant in intracellular vesicle membranes, but when it is needed vasopressin binds to the cell surface vasopressin receptor, activating a signaling pathway that causes the aquaporin 2 containing vesicles to fuse with the plasma membrane so the aquaporin 2 can be used by the cell.

      Images

      Western Blot analysis of COS7 cells with AQP2 Polyclonal Antibody.

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