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AR Polyclonal Antibody
Catalog number:E-AB-30543
Synonyms:AIS,ANDR,Androgen nuclear receptor variant 2,Androgen receptor (dihydrotestosterone receptor,testicular feminization,spinal and bulbar muscular atrophy,Kennedy disease),Androgen receptor,androgen receptor splice variant 4b,AR,AR8,DHTR,Dihydro testosterone receptor,Dihydrotestosterone receptor (DHTR),Dihydrotestosterone receptor,HUMARA,HYSP1,KD,Kennedy disease (KD),NR3C4,Nuclear receptor subfamily 3 group C member 4 (NR3C4),Nuclear receptor subfamily 3 group C member 4,SBMA,SMAX1,Spinal and bulbar muscular atrophy (SBMA),Spinal and bulbar muscular atrophy,Testicular Feminization (TFM),TFM
- 20 μL
- 60 μL
- 120 μL
- 200 μL
Host: Rabbit
Reactivity: H
Applications: WB,IHC-p,ELISA
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Overview
| Synonyms | AIS,ANDR,Androgen nuclear receptor variant 2,Androgen receptor (dihydrotestosterone receptor,testicular feminization,spinal and bulbar muscular atrophy,Kennedy disease),Androgen receptor,androgen receptor splice variant 4b,AR,AR8,DHTR,Dihydro testosterone receptor,Dihydrotestosterone receptor (DHTR),Dihydrotestosterone receptor,HUMARA,HYSP1,KD,Kennedy disease (KD),NR3C4,Nuclear receptor subfamily 3 group C member 4 (NR3C4),Nuclear receptor subfamily 3 group C member 4,SBMA,SMAX1,Spinal and bulbar muscular atrophy (SBMA),Spinal and bulbar muscular atrophy,Testicular Feminization (TFM),TFM |
| Swissprot | P10275 |
| Source | Rabbit |
| Reactivity | Human |
| Immunogen | Synthesized peptide derived from human AR around the non-phosphorylation site of Ser650. |
| Application | WB,IHC-p,ELISA |
| Recommended dilution | WB 1:500-1:2000, IHC 1:100-1:300, ELISA 1:40000 |
| Concentration | 1mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Nucleus. Cytoplasm. Predominantly cytoplasmic in unligated form but translocates to the nucleus upon ligand-binding. Can also translocate to the nucleus in unligated form in the presence of RACK1. |
| Tissue specificity | Isoform 2 is mainly expressed in heart and skeletal muscle (PubMed:15634333). Isoform 3 is expressed by basal and stromal cells of prostate (at protein level) (PubMed:19244107). |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4 |
| Background | Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3. |
Images
Western Blot analysis of 823 cells using AR Polyclonal Antibody at dilution of 1:500.
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