AURKB Polyclonal Antibody

Uniprot: Q96GD4
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
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    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience

      Catalog number:E-AB-30559

      Synonyms:AIK2,AIM-1,AIM1,ARK-2,ARK2,AurB,AURKB,AURKB,Aurora 1,Aurora and Ipl1 like midbody associated protein 1,Aurora kinase B,Aurora related kinase 2,Aurora- and Ipl1-like midbody-associated protein 1,Aurora-B,Aurora-related kinase 2,Aurora/IPL1 related kinase 2,Aurora/IPL1-related kinase 2,IPL1,PPP1R48,Protein phosphatase 1 regulatory subunit 48,Serine/theronine kinase 12,Serine/threonine protein kinase 12,Serine/threonine-protein kinase 12,Serine/threonine-protein kinase aurora-B,STK-1,STK1,STK12,STK5

      Size:
      • 20 μL
      • 60 μL
      • 120 μL
      • 200 μL
      Qty:
      - +
      Price: $69

      Host: Rabbit

      Reactivity: H,M,R

      Applications: WB,IHC-p,IF,ELISA

      Lead Time: 2 daysWelcome to order from local distributors.

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      Overview

      Synonyms AIK2,AIM-1,AIM1,ARK-2,ARK2,AurB,AURKB,AURKB,Aurora 1,Aurora and Ipl1 like midbody associated protein 1,Aurora kinase B,Aurora related kinase 2,Aurora- and Ipl1-like midbody-associated protein 1,Aurora-B,Aurora-related kinase 2,Aurora/IPL1 related kinase 2,Aurora/IPL1-related kinase 2,IPL1,PPP1R48,Protein phosphatase 1 regulatory subunit 48,Serine/theronine kinase 12,Serine/threonine protein kinase 12,Serine/threonine-protein kinase 12,Serine/threonine-protein kinase aurora-B,STK-1,STK1,STK12,STK5
      Swissprot Q96GD4
      Source Rabbit
      Reactivity Human,Mouse,Rat
      Immunogen Synthesized peptide derived from human ARK-2 around the non-phosphorylation site of Tyr12.
      Application WB,IHC-p,IF,ELISA
      Recommended dilution WB 1:500-1:2000, IHC 1:100-1:300, IF 1:200-1:1000, ELISA 1:40000
      Concentration 1mg/mL
      Clonality Polyclonal

      Properties

      Cellular localization Nucleus. Chromosome. Chromosome>centromere. Cytoplasm>cytoskeleton>spindle. Localizes on chromosome arms and inner centromeres from prophase through metaphase and then transferring to the spindle midzone and midbody from anaphase through cytokinesis. Colocalized with gamma tubulin in the mid-body.
      Tissue specificity High level expression seen in the thymus. It is also expressed in the spleen, lung, testis, colon, placenta and fetal liver. Expressed during S and G2/M phase and expression is up-regulated in cancer cells during M phase.
      Isotype IgG
      Purification Affinity purification
      Conjugation Unconjugated
      Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
      Storage buffer PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
      Background May be directly involved in regulating the cleavage of polar spindle microtubules and is a key regulator for the onset of cytokinesis during mitosis. Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Phosphorylates 'Ser-10' and 'Ser-28' of histone H3 during mitosis. Required for kinetochore localization of BUB1 and SGOL1. Interacts with INCENP.

      Images

      Western Blot analysis of HepG2 cells using AURKB Polyclonal Antibody at dilution of 1:500.

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