ATR Polyclonal Antibody

Uniprot: Q13535
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
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    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience

      Catalog number:E-AB-30608

      Synonyms:Ataxia telangiectasia and Rad3 related,Ataxia telangiectasia and Rad3-related protein,ATR,ATR,FCTCS,FRAP Related Protein 1,FRAP-related protein 1,FRP1,MEC1,MEC1 mitosis entry checkpoint 1 homolog,Protein kinase ATR,RAC3,Rad3 related protein,SCKL,SCKL1,Serine/threonine protein kinase ATR,Serine/threonine-protein kinase ATR

      Size:
      • 20μL
      • 60μL
      • 120μL
      • 200μL
      Qty:
      - +
      Price: $69

      Host: Rabbit

      Reactivity: H

      Applications: WB,IHC-p,ELISA

      Lead Time: 7~10 daysWelcome to order from local distributors.

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      Overview

      Synonyms Ataxia telangiectasia and Rad3 related,Ataxia telangiectasia and Rad3-related protein,ATR,ATR,FCTCS,FRAP Related Protein 1,FRAP-related protein 1,FRP1,MEC1,MEC1 mitosis entry checkpoint 1 homolog,Protein kinase ATR,RAC3,Rad3 related protein,SCKL,SCKL1,Serine/threonine protein kinase ATR,Serine/threonine-protein kinase ATR
      Swissprot Q13535
      Source Rabbit
      Reactivity Human
      Immunogen Synthesized peptide derived from human ATR around the non-phosphorylation site of S428.
      Application WB,IHC-p,ELISA
      Recommended dilution WB 1:500-1:2000, IHC 1:100-1:300, ELISA 1:40000
      Concentration 1mg/mL
      Clonality Polyclonal

      Properties

      Cellular localization Nucleus. Nucleus>PML body. Depending on the cell type, it can also be found in PML nuclear bodies. Recruited to chromatin during S-phase. Redistributes to discrete nuclear foci upon DNA damage, hypoxia or replication fork stalling.
      Tissue specificity Ubiquitous, with highest expression in testis. Isoform 2 is found in pancreas, placenta and liver but not in heart, testis and ovary.
      Isotype IgG
      Purification Affinity purification
      Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
      Storage buffer PBS with 0.02% sodium azide,0.5% BSA and 50% glycerol pH 7.4.
      Background The protein encoded by this gene belongs the PI3/PI4-kinase family, and is most closely related to ATM, a protein kinase encoded by the gene mutated in ataxia telangiectasia. This protein and ATM share similarity with Schizosaccharomyces pombe rad3, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This kinase has been shown to phosphorylate checkpoint kinase CHK1, checkpoint proteins RAD17, and RAD9, as well as tumor suppressor protein BRCA1. Mutations of this gene are associated with Seckel syndrome. An alternatively spliced transcript variant of this gene has been reported, however, its full length nature is not known. Transcript variants utilizing alternative polyA sites exist.

      Images

      Western Blot analysis of COLO cells with ATR Polyclonal Antibody.

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