BARD1 Polyclonal Antibody

Uniprot: Q99728
  • polyclonal antibody-Elabscience
  • polyclonal antibody-Elabscience
  • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
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    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience

      Catalog number:E-AB-30626

      Synonyms:BARD-1,Bard1,BARD1,BRCA1 associated RING domain 1,BRCA1 associated RING domain gene 1,BRCA1 associated RING domain protein 1,BRCA1-associated RING domain protein 1

      Size:
      • 20 μL
      • 60 μL
      • 120 μL
      • 200 μL
      Qty:
      - +
      Price: $69

      Host: Rabbit

      Reactivity: H

      Applications: WB,IHC-p,ELISA

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      Overview

      Synonyms BARD-1,Bard1,BARD1,BRCA1 associated RING domain 1,BRCA1 associated RING domain gene 1,BRCA1 associated RING domain protein 1,BRCA1-associated RING domain protein 1
      Swissprot Q99728
      Source Rabbit
      Reactivity Human
      Immunogen Synthesized peptide derived from the N-terminal region of human BARD1
      Application WB,IHC-p,ELISA
      Recommended dilution WB 1:500-1:2000, IHC 1:100-1:300, ELISA 1:5000
      Concentration 1mg/mL
      Clonality Polyclonal

      Properties

      Cellular localization Nucleus. During S phase of the cell cycle, colocalizes with BRCA1 into discrete subnuclear foci. Can translocate to the cytoplasm. Localizes at sites of DNA damage at double-strand breaks (DSBs); recruitment to DNA damage sites is mediated by the BRCA1-A complex.
      Isotype IgG
      Purification Affinity purification
      Conjugation Unconjugated
      Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
      Storage buffer PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
      Background This gene encodes a protein which interacts with the N-terminal region of BRCA1. In addition to its ability to bind BRCA1 in vivo and in vitro, it shares homology with the 2 most conserved regions of BRCA1: the N-terminal RING motif and the C-terminal BRCT domain. The RING motif is a cysteine-rich sequence found in a variety of proteins that regulate cell growth, including the products of tumor suppressor genes and dominant protooncogenes. This protein also contains 3 tandem ankyrin repeats. The BARD1/BRCA1 interaction is disrupted by tumorigenic amino acid substitutions in BRCA1, implying that the formation of a stable complex between these proteins may be an essential aspect of BRCA1 tumor suppression. This protein may be the target of oncogenic mutations in breast or ovarian cancer. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.BARD1 (BRCA1 Associated RING Domain 1) is a Protein Coding gene. Diseases associated with BARD1 include Breast Cancer and Familial Breast Cancer. Among its related pathways are DNA Double-Strand Break Repair and Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA). GO annotations related to this gene include protein homodimerization activity and protein heterodimerization activity. An important paralog of this gene is TONSL.

      Images

      Western Blot analysis of Hela cells with BARD1 Polyclonal Antibody.

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