Bim Polyclonal Antibody

Uniprot: O43521
  • polyclonal antibody-Elabscience
  • polyclonal antibody-Elabscience
  • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
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    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience

      Catalog number:E-AB-30650

      Synonyms:BCL2 like 11,B2L11,BAM,Bcl 2 interacting protein Bim,Bcl 2 related ovarian death agonist,Bcl-2-like protein 11,BCL2 interacting mediator of cell death,BCL2 like 11 (apoptosis facilitator),BCL2 like protein 11,Bcl2-interacting mediator of cell death,Bcl2-L-11,Bcl2l11,BIM alpha6,BIM,BIM beta6,BIM beta7,BimEL,BimL,BOD

      Size:
      • 20 μL
      • 60 μL
      • 120 μL
      • 200 μL
      Qty:
      - +
      Price: $69

      Host: Rabbit

      Reactivity: H,M,R,Mk

      Applications: WB,IHC-p,ELISA

      Lead Time: 2 daysWelcome to order from local distributors.

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      Overview

      Synonyms BCL2 like 11,B2L11,BAM,Bcl 2 interacting protein Bim,Bcl 2 related ovarian death agonist,Bcl-2-like protein 11,BCL2 interacting mediator of cell death,BCL2 like 11 (apoptosis facilitator),BCL2 like protein 11,Bcl2-interacting mediator of cell death,Bcl2-L-11,Bcl2l11,BIM alpha6,BIM,BIM beta6,BIM beta7,BimEL,BimL,BOD
      Swissprot O43521
      Source Rabbit
      Reactivity Human,Mouse,Rat,Monkey
      Immunogen Synthesized peptide derived from the N-terminal region of human Bim
      Application WB,IHC-p,ELISA
      Recommended dilution WB 1:500-1:2000, IHC 1:100-1:300, ELISA 1:20000
      Concentration 1mg/mL
      Clonality Polyclonal

      Properties

      Cellular localization Mitochondrion and Endomembrane system. Associated with intracytoplasmic membranes.
      Tissue specificity Isoform BimEL, isoform BimL and isoform BimS are the predominant isoforms and are ubiquitously expressed with a tissue-specific variation. Isoform Bim-gamma is most abundantly expressed in small intestine and colon, and in lower levels in spleen, prostate, testis, heart, liver and kidney.
      Isotype IgG
      Purification Affinity purification
      Conjugation Unconjugated
      Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
      Storage buffer PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
      Background The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified.

      Images

      Western Blot analysis of Hela cells with Bim Polyclonal Antibody.

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