BRSK1 Polyclonal Antibody

Uniprot: Q8TDC3
  • polyclonal antibody-Elabscience
  • polyclonal antibody-Elabscience
  • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
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    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience

      Catalog number:E-AB-30676

      Synonyms:BR serine/threonine kinase 1,BR serine/threonine protein kinase 1,BR serine/threonine-protein kinase 1,Brain selective kinase 1,Brain-specific serine/threonine-protein kinase 1,BRSK 1,Brsk1,BRSK1,FLJ43009,hSAD1,KIAA1811,Protein kinase SAD1A,SAD 1,SAD1,SAD1 homolog,SAD1 kinase,SAD1A,SADB,SadB kinase short isoform,Serine/threonine kinase SAD B,Serine/threonine-protein kinase SAD-B,Synapses of Amphids Defective homolog

      Size:
      • 20μL
      • 60μL
      • 120μL
      • 200μL
      Qty:
      - +
      Price: $69

      Host: Rabbit

      Reactivity: H,M

      Applications: WB,IF,ELISA

      Lead Time: 7~10 daysWelcome to order from local distributors.

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      Overview

      Synonyms BR serine/threonine kinase 1,BR serine/threonine protein kinase 1,BR serine/threonine-protein kinase 1,Brain selective kinase 1,Brain-specific serine/threonine-protein kinase 1,BRSK 1,Brsk1,BRSK1,FLJ43009,hSAD1,KIAA1811,Protein kinase SAD1A,SAD 1,SAD1,SAD1 homolog,SAD1 kinase,SAD1A,SADB,SadB kinase short isoform,Serine/threonine kinase SAD B,Serine/threonine-protein kinase SAD-B,Synapses of Amphids Defective homolog
      Swissprot Q8TDC3
      Source Rabbit
      Reactivity Human,Mouse
      Immunogen Synthesized peptide derived from the Internal region of human BRSK1
      Application WB,IF,ELISA
      Recommended dilution WB 1:500-1:2000, IF 1:200-1:1000, ELISA 1:5000
      Concentration 1mg/mL
      Clonality Polyclonal

      Properties

      Cellular localization Cytoplasm. Nucleus. Nuclear in the absence of DNA damage. Translocated to the nucleus in response to UV- or MMS-induced DNA damage.
      Tissue specificity Widely expressed, with highest levels in brain and testis. Protein levels remain constant throughout the cell cycle.
      Isotype IgG
      Purification Affinity purification
      Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
      Storage buffer PBS with 0.02% sodium azide,0.5% BSA and 50% glycerol pH 7.4.
      Background The phosphorylation and dephosphorylation of proteins on serine and threonine residues is an essential means of regulating a broad range of cellular functions in eukaryotes, including cell division, homeostasis and apoptosis. A group of proteins that are intimately involved in this process are the serine/threonine (Ser/Thr) protein kinases. BRSK1 (BR serine/threonine-protein kinase 1), also known as SAD1, is a 794 amino acid protein that localizes to both the nucleus and the cytoplasm and contains one UBA domain and one protein kinase domain. Expressed in a variety of tissues with highest expression in testis and brain, BRSK1 uses magensium as a cofactor to catalyze the ATP-dependent phosphorylation of target proteins, including Wee 1 and Cdc25B. Via its kinase activity toward proteins that are involved in microtubule assembly, BRSK1 plays an essential role in neuronal polarization and may be involved in regulating cell cycle arrest in response to DNA damage, Two isoforms of BRSK1 exist due to alternative splicing events.

      Images

      Western Blot analysis of 293 cells with BRSK1 Polyclonal Antibody.

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