c-Myc Polyclonal Antibody

Uniprot : P01106
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      Catalog number:E-AB-62131

      Synonyms:AU016757,Avian myelocytomatosis viral oncogene homolog,bHLHe39,c Myc,Class E basic helix-loop-helix protein 39,MRTL,Myc,Myc protein,Myc proto oncogene protein,Myc proto-oncogene protein,myc-related translation/localization regulatory factor,MYC,Myc2,MYCC,Myelocytomatosis oncogene,Niard,Nird,Oncogene Myc,OTTHUMP00000158589,Proto-oncogene c-Myc,Protooncogene homologous to myelocytomatosis virus,RNCMYC,Transcription factor p64,Transcriptional regulator Myc-A,V-Myc avian myelocytomatosis viral oncogene homolog,v-myc myelocytomatosis viral oncogene homolog (avian)

      Size:
      • 60μL
      • 120μL
      • 200μL
      Qty:
      - +
      Price: $129

      Host: Rabbit

      Reactivity: H,M,R

      Applications: WB

      Lead Time: 7~10 daysWelcome to order from local distributors.

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      Overview

      Synonyms AU016757,Avian myelocytomatosis viral oncogene homolog,bHLHe39,c Myc,Class E basic helix-loop-helix protein 39,MRTL,Myc,Myc protein,Myc proto oncogene protein,Myc proto-oncogene protein,myc-related translation/localization regulatory factor,MYC,Myc2,MYCC,Myelocytomatosis oncogene,Niard,Nird,Oncogene Myc,OTTHUMP00000158589,Proto-oncogene c-Myc,Protooncogene homologous to myelocytomatosis virus,RNCMYC,Transcription factor p64,Transcriptional regulator Myc-A,V-Myc avian myelocytomatosis viral oncogene homolog,v-myc myelocytomatosis viral oncogene homolog (avian)
      Swissprot P01106
      Source Rabbit
      Reactivity Human,Mouse,Rat
      Immunogen A synthetic peptide of human MYC
      Application WB
      Recommended dilution WB 1:500 - 1:2000
      Concentration 1mg/ml
      Clonality Polyclonal

      Properties

      Cellular localization Nucleus > nucleoplasm. Nucleus > nucleolus.
      Isotype IgG
      Purification Affinity purification
      Conjugation Unconjugated
      Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
      Storage buffer PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
      Background The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene.

      Images

      Western blot analysis of extracts of rat brain with c-Myc Polyclonal Antibody

      Western blot analysis of extracts of various cell lines with c-Myc Polyclonal Antibody

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