CHP2 Polyclonal Antibody

Uniprot : O43745
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
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    >
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience

      Catalog number:E-AB-30926

      Synonyms:CHP2,HCA520,Calcineurin B homologous protein 2,Hepatocellular carcinoma-associated antigen 520

      Size:
      • 20 μL
      • 60 μL
      • 120 μL
      • 200 μL
      Qty:
      - +
      Price: $69

      Host: Rabbit

      Reactivity: H,M,R

      Applications: WB,ELISA

      Lead Time: 2 daysWelcome to order from local distributors.

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      Overview

      Synonyms CHP2,HCA520,Calcineurin B homologous protein 2,Hepatocellular carcinoma-associated antigen 520
      Swissprot O43745
      Source Rabbit
      Reactivity Human,Mouse,Rat
      Immunogen Synthesized peptide derived from the Internal region of human CHP2
      Application WB,ELISA
      Recommended dilution WB 1:500-1:2000, ELISA 1:40000
      Concentration 1mg/mL
      Clonality Polyclonal

      Properties

      Cellular localization Nucleus,Plasma Membrane,Other locations:cytoplasm
      Tissue specificity Expressed in malignantly transformed cells but not detected in normal tissues.
      Isotype IgG
      Purification Affinity purification
      Conjugation Unconjugated
      Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
      Storage buffer PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
      Background This gene product is a small calcium-binding protein that regulates cell pH by controlling plasma membrane-type Na+/H+ exchange activity. This protein shares sequence similarity with calcineurin B and can bind to and stimulate the protein phosphatase activity of calcineurin A (CnA) and functions in the calcineurin/NFAT (nuclear factor of activated T cells) signaling pathway. Another member of the CHP subfamily, Calcineurin B homologous protein 1, is located on Chromosome 15 and is an inhibitor of calcineurin activity and has a genetic phenotype associated with Parkinson's Disease (OMIM:606988). This gene was initially identified as a tumor-associated antigen and was previously referred to as Hepatocellular carcinoma-associated antigen 520.CHP2 (Calcineurin Like EF-Hand Protein 2) is a Protein Coding gene. Diseases associated with CHP2 include Hepatocellular Carcinoma. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is CHP1.

      Images

      Western Blot analysis of HT29 cells with CHP2 Polyclonal Antibody.

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