CLCN4 Polyclonal Antibody

Uniprot: P51793
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
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    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience

      Catalog number:E-AB-30948

      Synonyms:Chloride channel 4,Chloride channel protein 4,Chloride channel,voltage sensitive 4,Chloride transporter ClC-4,ClC 4A,ClC-4,CLC4,ClC4A,CLCN4,CLCN4,H(+)/Cl(-) exchange transporter 4,MGC163150

      Size:
      • 20 μL
      • 60 μL
      • 120 μL
      • 200 μL
      Qty:
      - +
      Price: $69

      Host: Rabbit

      Reactivity: H,M,R

      Applications: WB,IF,ELISA

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      Overview

      Synonyms Chloride channel 4,Chloride channel protein 4,Chloride channel,voltage sensitive 4,Chloride transporter ClC-4,ClC 4A,ClC-4,CLC4,ClC4A,CLCN4,CLCN4,H(+)/Cl(-) exchange transporter 4,MGC163150
      Swissprot P51793
      Source Rabbit
      Reactivity Human,Mouse,Rat
      Immunogen Synthesized peptide derived from the Internal region of human CLC-4
      Application WB,IF,ELISA
      Recommended dilution WB 1:500-1:2000, IF 1:100-1:300, ELISA 1:40000
      Concentration 1mg/mL
      Clonality Polyclonal

      Properties

      Cellular localization Early endosome membrane. Late endosome membrane.
      Tissue specificity Abundant in skeletal muscle and also detectable in brain and heart.
      Isotype IgG
      Purification Affinity purification
      Conjugation Unconjugated
      Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
      Storage buffer PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
      Background The CLCN family of voltage-dependent chloride channel genes comprises nine members (CLCN1-7, Ka and Kb) which demonstrate quite diverse functional characteristics while sharing significant sequence homology. Chloride channel 4 has an evolutionary conserved CpG island and is conserved in both mouse and hamster. This gene is mapped in close proximity to APXL (Apical protein Xenopus laevis-like) and OA1 (Ocular albinism type I), which are both located on the human X chromosome at band p22.3. The physiological role of chloride channel 4 remains unknown but may contribute to the pathogenesis of neuronal disorders. Alternate splicing results in two transcript variants that encode different proteins.CLCN4 (Chloride Voltage-Gated Channel 4) is a Protein Coding gene. Diseases associated with CLCN4 include Mental Retardation, X-Linked 49 and Non-Syndromic X-Linked Intellectual Disability. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Ion channel transport. GO annotations related to this gene include ion channel activity and antiporter activity. An important paralog of this gene is CLCN5.

      Images

      Western Blot analysis of 3T3 cells using CLCN4 Polyclonal Antibody at dilution of 1:500.

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