CLU Polyclonal Antibody

Uniprot: P10909
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    <
    >
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience

      Catalog number:E-AB-30965

      Synonyms:40,AAG 4,AAG4,Aging associated protein 4,Aging-associated gene 4 protein,AI893575,APO J,Apo-J,APOJ,ApoJalpha,ApoJbeta,Apolipoprotein J,ApolipoproteinJ,CLI,CLU,CLU1,CLU2,CLUS,Clusterin alpha chain,Clusterin,Clusterin beta chain,Complement associated protein SP 40 40,Complement associated protein SP 40,Complement associated protein SP40,Complement cytolysis inhibitor a chain,Complement cytolysis inhibitor,Complement cytolysis inhibitor b chain,Complement lysis inhibitor,Complement-associated protein SP-40,D14Ucla3,Dimeric acid glycoprotein,Glycoprotein 80,Glycoprotein III,GP80,Ku70-binding protein 1,KUB 1,KUB1,MGC24903,NA1/NA2,RATTRPM2B,SGP 2,SGP2,SP 40,SP40,Sugp-2,Sulfated glycoprotein 2,Testosterone repressed prostate message 2,Testosterone-repressed prostate message 2,TRPM 2,TRPM-2,TRPM2,TRPM2B,Trpmb

      Size:
      • 20 μL
      • 60 μL
      • 120 μL
      • 200 μL
      Qty:
      - +
      Price: $69

      Host: Rabbit

      Reactivity: H,M,R

      Applications: WB,IHC-p,IF,ELISA

      Lead Time: 2 daysWelcome to order from local distributors.

      Add to cart Compare Bulk request Manual

      Overview

      Synonyms 40,AAG 4,AAG4,Aging associated protein 4,Aging-associated gene 4 protein,AI893575,APO J,Apo-J,APOJ,ApoJalpha,ApoJbeta,Apolipoprotein J,ApolipoproteinJ,CLI,CLU,CLU1,CLU2,CLUS,Clusterin alpha chain,Clusterin,Clusterin beta chain,Complement associated protein SP 40 40,Complement associated protein SP 40,Complement associated protein SP40,Complement cytolysis inhibitor a chain,Complement cytolysis inhibitor,Complement cytolysis inhibitor b chain,Complement lysis inhibitor,Complement-associated protein SP-40,D14Ucla3,Dimeric acid glycoprotein,Glycoprotein 80,Glycoprotein III,GP80,Ku70-binding protein 1,KUB 1,KUB1,MGC24903,NA1/NA2,RATTRPM2B,SGP 2,SGP2,SP 40,SP40,Sugp-2,Sulfated glycoprotein 2,Testosterone repressed prostate message 2,Testosterone-repressed prostate message 2,TRPM 2,TRPM-2,TRPM2,TRPM2B,Trpmb
      Swissprot P10909
      Source Rabbit
      Reactivity Human,Mouse,Rat
      Immunogen Synthesized peptide derived from the C-terminal region of human Clusterin
      Application WB,IHC-p,IF,ELISA
      Recommended dilution WB 1:500-1:2000, IHC 1:100-1:300, IF 1:200-1:1000, ELISA 1:20000
      Concentration 1mg/mL
      Clonality Polyclonal

      Properties

      Cellular localization Secreted. Can retrotranslocate from the secretory compartments to the cytosol upon cellular stress and Nucleus. Cytoplasm. Mitochondrion membrane. Cytoplasm, cytosol. Microsome. Endoplasmic reticulum. Cytoplasmic vesicle, secretory vesicle, chromaffin granule. Isoforms lacking the N-terminal signal sequence have been shown to be cytoplasmic and/or nuclear. Secreted isoforms can retrotranslocate from the secretory compartments to the cytosol upon cellular stress. Detected in perinuclear foci that may be aggresomes containing misfolded, ubiquitinated proteins. Detected at the mitochondrion membrane upon induction of apoptosis.
      Tissue specificity Detected in blood plasma, cerebrospinal fluid, milk, seminal plasma and colon mucosa. Detected in the germinal center of colon lymphoid nodules and in colon parasympathetic ganglia of the Auerbach plexus (at protein level). Ubiquitous. Detected in brain, testis, ovary, liver and pancreas, and at lower levels in kidney, heart, spleen and lung.
      Isotype IgG
      Purification Affinity purification
      Conjugation Unconjugated
      Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
      Storage buffer PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
      Background Isoform 1 functions as extracellular chaperone that prevents aggregation of nonnative proteins. Prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosomal or proteasomal degradation. Secreted isoform 1 protects cells against apoptosis and against cytolysis by complement. Intracellular isoforms interact with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes and promote the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes proteasomal degradation of COMMD1 and IKBKB. Modulates NF-kappa-B transcriptional activity. Nuclear isoforms promote apoptosis. Mitochondrial isoforms suppress BAX-dependent release of cytochrome c into the cytoplasm and inhibit apoptosis. Plays a role in the regulation of cell proliferation.

      Images

      Western Blot analysis of Hela cells with CLU Polyclonal Antibody

      • Show all (0)
      • Reviews (0)
      • Q&A (0)
      ... Show All Show Less

      Browsing History


        People Also Bought