COL1A2 Polyclonal Antibody

Uniprot: P08123
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
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    >
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience

      Catalog number:E-AB-30989

      Synonyms:Alpha 2 collagen type I,Alpha 2 type I collagen,Alpha 2 type I procollagen,Alpha 2(I) collagen,Alpha 2(I) procollagen,Alpha-2 type I collagen,CO1A2,COL1A2,Collagen alpha 2(I) chain,Collagen alpha-2(I) chain,Collagen I alpha 2 polypeptide,Collagen of skin tendon and bone alpha 2 chain,Collagen type I alpha 2,OI4,Osteogenesis imperfecta type IV,Type I procollagen

      Size:
      • 20μL
      • 60μL
      • 120μL
      • 200μL
      Qty:
      - +
      Price: $69

      Host: Rabbit

      Reactivity: H

      Applications: WB,IHC-p,IF,ELISA

      Lead Time: 7~10 daysWelcome to order from local distributors.

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      Overview

      Synonyms Alpha 2 collagen type I,Alpha 2 type I collagen,Alpha 2 type I procollagen,Alpha 2(I) collagen,Alpha 2(I) procollagen,Alpha-2 type I collagen,CO1A2,COL1A2,Collagen alpha 2(I) chain,Collagen alpha-2(I) chain,Collagen I alpha 2 polypeptide,Collagen of skin tendon and bone alpha 2 chain,Collagen type I alpha 2,OI4,Osteogenesis imperfecta type IV,Type I procollagen
      Swissprot P08123
      Source Rabbit
      Reactivity Human
      Immunogen Synthesized peptide derived from the Internal region of human COL1A2
      Application WB,IHC-p,IF,ELISA
      Recommended dilution WB 1:500-1:2000, IHC 1:100-1:300, IF 1:200-1:1000, ELISA 1:20000
      Concentration 1mg/mL
      Clonality Polyclonal

      Properties

      Cellular localization Secreted>extracellular space>extracellular matrix.
      Tissue specificity Forms the fibrils of tendon, ligaments and bones. In bones the fibrils are mineralized with calcium hydroxyapatite.
      Isotype IgG
      Purification Affinity purification
      Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
      Storage buffer PBS with 0.02% sodium azide,0.5% BSA and 50% glycerol pH 7.4.
      Background This gene encodes the pro-alpha2 chain of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIB, recessive Ehlers-Danlos syndrome Classical type, idiopathic osteoporosis, and atypical Marfan syndrome. Symptoms associated with mutations in this gene, however, tend to be less severe than mutations in the gene for the alpha1 chain of type I collagen (COL1A1) reflecting the different role of alpha2 chains in matrix integrity. Three transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene. 

      Images

      Western Blot analysis of COLO205 cells using COL1A2 Polyclonal Antibody at dilution of 1:1000.

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