Synonyms:COL4A6,Collagen Alpha 6(IV),Collagen alpha 6(IV) chain,Collagen IV alpha 6 polypeptide,Collagen of basement membrane alpha 6,Collagen type IV alpha 6,dJ889N15.4,MGC88184,Type IV alpha 6 collagen
|Synonyms||COL4A6,Collagen Alpha 6(IV),Collagen alpha 6(IV) chain,Collagen IV alpha 6 polypeptide,Collagen of basement membrane alpha 6,Collagen type IV alpha 6,dJ889N15.4,MGC88184,Type IV alpha 6 collagen|
|Immunogen||Synthesized peptide derived from the C-terminal region of human COL4A6|
|Recommended dilution||WB 1:500-1:2000, IHC 1:100-1:300, IF 1:200-1:1000, ELISA 1:40000|
|Storage instructions||Store at -20℃. Avoid freeze / thaw cycles.|
|Storage buffer||PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4|
|Background||This gene encodes one of the six subunits of type IV collagen, the major structural component of basement membranes. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene, alpha 5 type IV collagen, so that the gene pair shares a common promoter. Deletions in the alpha 5 gene that extend into the alpha 6 gene result in diffuse leiomyomatosis accompanying the X-linked Alport syndrome caused by the deletion in the alpha 5 gene. Alternative splicing results in multiple transcript variants encoding different isoforms.COL4A6 (Collagen Type IV Alpha 6 Chain) is a Protein Coding gene. Diseases associated with COL4A6 include Deafness, X-Linked 6 and X-Linked Non-Syndromic Sensorineural Deafness Type Dfn. Among its related pathways are Collagen chain trimerization and Phospholipase-C Pathway. GO annotations related to this gene include structural molecule activity and extracellular matrix structural constituent. An important paralog of this gene is COL4A2.|
Western Blot analysis of HepG2 cells using COL4A6 Polyclonal Antibody at dilution of 1:500.