Synonyms:Collagen alpha 1(IX) chain,Collagen type IX alpha 1,EDM6,MED,STL4
|Synonyms||Collagen alpha 1(IX) chain,Collagen type IX alpha 1,EDM6,MED,STL4|
|Immunogen||Synthesized peptide derived from the Internal region of human COL9A1|
|Recommended dilution||WB 1:500-1:2000, IHC 1:100-1:300, ELISA 1:5000|
|Storage instructions||Store at -20℃. Avoid freeze / thaw cycles.|
|Storage buffer||PBS with 0.02% sodium azide,0.5% BSA and 50% glycerol pH 7.4.|
|Background||This gene encodes one of the three alpha chains of type IX collagen, which is a minor (5-20%) collagen component of hyaline cartilage. Type IX collagen is usually found in tissues containing type II collagen, a fibrillar collagen. Studies in knockout mice have shown that synthesis of the alpha 1 chain is essential for assembly of type IX collagen molecules, a heterotrimeric molecule, and that lack of type IX collagen is associated with early onset osteoarthritis. Mutations in this gene are associated with osteoarthritis in humans, with multiple epiphyseal dysplasia, 6, a form of chondrodysplasia, and with Stickler syndrome, a disease characterized by ophthalmic, orofacial, articular, and auditory defects. Two transcript variants that encode different isoforms have been identified for this gene.|
Western Blot analysis of HepG2 cells with COL9A1 Polyclonal Antibody.