F10 Polyclonal Antibody

Uniprot : P00742
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
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    >
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience

      Catalog number:E-AB-14397

      Synonyms:Activated factor Xa heavy chain,Coagulation factor X,F10,FA10,factor Xa,FX,FXA,Prothrombinase,Stuart factor,Stuart Prower factor,Stuart-Prower factor

      Size:
      • 20μL
      • 60μL
      • 120μL
      • 200μL
      Qty:
      - +
      Price: $69

      Host: Rabbit

      Reactivity: H,M,R

      Applications: WB,ELISA

      Lead Time: 7~10 daysWelcome to order from local distributors.

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      Overview

      Synonyms Activated factor Xa heavy chain,Coagulation factor X,F10,FA10,factor Xa,FX,FXA,Prothrombinase,Stuart factor,Stuart Prower factor,Stuart-Prower factor
      Swissprot P00742
      Source Rabbit
      Reactivity Human,Mouse,Rat
      Immunogen Recombinant protein of human F10
      Application WB(Detection kit: E-IR-R304),ELISA
      Recommended dilution WB 1:200-1:1000
      Concentration 0.1 mg/mL
      Clonality Polyclonal

      Properties

      Cellular localization Secreted.
      Tissue specificity Plasma; synthesized in the liver.
      Isotype IgG
      Purification Affinity purification
      Conjugation Unconjugated
      Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
      Storage buffer PBS with 0.05% sodium azide and 50% glycerol, PH7.4
      Background This gene encodes the vitamin K-dependent coagulation factor X of the blood coagulation cascade. This factor undergoes multiple processing steps before its preproprotein is converted to a mature two-chain form by the excision of the tripeptide RKR. Two chains of the factor are held together by 1 or more disulfide bonds; the light chain contains 2 EGF-like domains, while the heavy chain contains the catalytic domain which is structurally homologous to those of the other hemostatic serine proteases. The mature factor is activated by the cleavage of the activation peptide by factor IXa (in the intrisic pathway), or by factor VIIa (in the extrinsic pathway). The activated factor then converts prothrombin to thrombin in the presence of factor Va, Ca+2, and phospholipid during blood clotting. Mutations of this gene result in factor X deficiency, a hemorrhagic condition of variable severity.

      Images

      Western Blot analysis of A431 cell using F10 Polyclonal Antibody at dilution of 1:200

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