FGF2 Polyclonal Antibody

Uniprot : P13109
    • polyclonal antibody-Elabscience
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    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience

      Catalog number:E-AB-40259

      Synonyms:Basic fibroblast growth factor,Basic fibroblast growth factor bFGF,BFGF,FGF 2,FGF B,FGF-2,Fgf2,FGF2 basic,FGF2,FGFB,Fibroblast growth factor 2 (basic),Fibroblast growth factor 2,Fibroblast growth factor,basic,HBGF 2,HBGF-2,HBGF2,HBGH 2,HBGH2,Heparin binding growth factor 2 precursor,Heparin-binding growth factor 2,Prostatropin

      Size:
      • 20μL
      • 60μL
      • 120μL
      • 200μL
      Qty:
      - +
      Price: $60

      Host: Rabbit

      Reactivity: M,R

      Applications: IHC

      Lead Time: 7~10 daysWelcome to order from local distributors.

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      Overview

      Synonyms Basic fibroblast growth factor,Basic fibroblast growth factor bFGF,BFGF,FGF 2,FGF B,FGF-2,Fgf2,FGF2 basic,FGF2,FGFB,Fibroblast growth factor 2 (basic),Fibroblast growth factor 2,Fibroblast growth factor,basic,HBGF 2,HBGF-2,HBGF2,HBGH 2,HBGH2,Heparin binding growth factor 2 precursor,Heparin-binding growth factor 2,Prostatropin
      Swissprot P13109
      Source Rabbit
      Reactivity Mouse,Rat
      Immunogen Recombinant Rat Fibroblast growth factor 2 protein
      Application IHC(Detection kit: E-IR-R213)
      Recommended dilution IHC 1:100-1:200
      Concentration 0.66 mg/mL

      Properties

      Cellular localization Secreted. Nucleus. Exported from cells by an endoplasmic reticulum (ER)/Golgi-independent mechanism. Unconventional secretion of FGF2 occurs by direct translocation across the plasma membrane. Binding of exogenous FGF2 to FGFR facilitates endocytosis followed by translocation of FGF2 across endosomal membrane into the cytosol. Nuclear import from the cytosol requires the classical nuclear import machinery, involving proteins KPNA1 and KPNB1, as well as CEP57.
      Tissue specificity Found in all tissues examined.Highest expression level in skeletal muscle tissue.
      Isotype IgG
      Purification Antigen Affinity Purification
      Conjugation Unconjugated
      Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
      Storage buffer PBS with 0.05% Proclin300 and 50% glycerol, pH7.4.
      Background The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members bind heparin and possess broad mitogenic and angiogenic activities. This protein has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. The mRNA for this gene contains multiple polyadenylation sites, and is alternatively translated from non-AUG (CUG) and AUG initiation codons, resulting in five different isoforms with distinct properties. The CUG-initiated isoforms are localized in the nucleus and are responsible for the intracrine effect, whereas, the AUG-initiated form is mostly cytosolic and is responsible for the paracrine and autocrine effects of this FGF.

      Images

      Immunohistochemistry of paraffin-embedded Rat brain using Fgf2 Polyclonal Antibody at dilution of 1:100

      Immunohistochemistry of paraffin-embedded Mouse brain using Fgf2 Polyclonal Antibody at dilution of 1:100

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