GRK4 Polyclonal Antibody

Uniprot : P32298
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
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    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience

      Catalog number:E-AB-14112

      Synonyms:G protein coupled receptor kinase 4,G protein-coupled receptor kinase 2 (Drosophila)-like,G protein-coupled receptor kinase 4,G protein-coupled receptor kinase GRK4,G proteinm coupled receptor kinase GRK4,GPRK2L,GPRK4,GRK4,GRK4,GRK4a,ITI1

      Size:
      • 20μL
      • 60μL
      • 120μL
      • 200μL
      Qty:
      - +
      Price: $69

      Host: Rabbit

      Reactivity: H

      Applications: WB,IHC,ELISA

      Lead Time: 7~10 daysWelcome to order from local distributors.

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      Overview

      Synonyms G protein coupled receptor kinase 4,G protein-coupled receptor kinase 2 (Drosophila)-like,G protein-coupled receptor kinase 4,G protein-coupled receptor kinase GRK4,G proteinm coupled receptor kinase GRK4,GPRK2L,GPRK4,GRK4,GRK4,GRK4a,ITI1
      Swissprot P32298
      Source Rabbit
      Reactivity Human
      Immunogen Recombinant protein of human GRK4
      Application WB(Detection kit: E-IR-R304),IHC(Detection kit: E-IR-R213),ELISA
      Recommended dilution WB 1:1000-1:5000, IHC 1:50-1:200
      Concentration 0.3 mg/mL
      Clonality Polyclonal

      Properties

      Cellular localization Cytoplasm. Cytoplasm>cell cortex. Both at the cell surface and dispersed in the cytoplasm under basal conditions. Receptor stimulation results in the internalization of GRK4 to the perinuclear area, where co-localization with DRD3 is observed strongly at 5 and 15 minutes. DRD3 and GRK4 co-localize in lipid rafts of renal proximal tubule cells.
      Tissue specificity Isoform 1, isoform 2, isoform 3, and isoform 4 are expressed in testis. Isoform 4 is expressed in myometrium.
      Isotype IgG
      Purification Affinity purification
      Conjugation Unconjugated
      Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
      Storage buffer PBS with 0.05% sodium azide and 50% glycerol, PH7.4
      Background This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating its deactivation. This gene has been linked to both genetic and acquired hypertension. Specifically phosphorylates the activated forms of G protein-coupled receptors. GRK4-alpha can phosphorylate rhodopsin and its activity is inhibited by calmodulin; the other three isoforms do not phosphorylate rhodopsin and do not interact with calmodulin. GRK4-alpha and GRK4-gamma phosphorylate DRD3. Phosphorylates ADRB2.

      Images

      Western Blot analysis of Hela and Jurkat cell using GRK4 Polyclonal Antibody at dilution of 1:700

      Immunohistochemistry of paraffin-embedded Human liver cancer using GRK4 Polyclonal Antibody at dilution of 1:40

      Immunohistochemistry of paraffin-embedded Human ovarian cancer using GRK4 Polyclonal Antibody at dilution of 1:40

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