HPSE Polyclonal Antibody

Uniprot : Q9Y251
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
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    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience

      Catalog number:E-AB-14130

      Synonyms:Endo glucoronidase,Endo-glucoronidase,HEP,Heparanase 50 kDa subunit,Heparanase,Heparanase-1,Heparanase1,Hpa 1,HPA,Hpa1,HPR 1,HPR1,HPSE 1,HPSE,HPSE,HPSE1,HSE 1,HSE1

      Size:
      • 20μL
      • 60μL
      • 120μL
      • 200μL
      Qty:
      - +
      Price: $69

      Host: Rabbit

      Reactivity: H

      Applications: WB,ELISA

      Lead Time: 7~10 daysWelcome to order from local distributors.

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      Overview

      Synonyms Endo glucoronidase,Endo-glucoronidase,HEP,Heparanase 50 kDa subunit,Heparanase,Heparanase-1,Heparanase1,Hpa 1,HPA,Hpa1,HPR 1,HPR1,HPSE 1,HPSE,HPSE,HPSE1,HSE 1,HSE1
      Swissprot Q9Y251
      Source Rabbit
      Reactivity Human
      Immunogen Recombinant protein of human HPSE
      Application WB(Detection kit: E-IR-R304),ELISA
      Recommended dilution WB 1:500-1:2000
      Concentration 0.4 mg/mL
      Clonality Polyclonal

      Properties

      Cellular localization Lysosome membrane. Secreted. Secreted, internalised and transferred to late endosomes/lysosomes as a proheparanase. In lysosomes, it is processed into the active form, the heparanase. The uptake or internalisation of proheparanase is mediated by HSPGs. Heparin appears to be a competitor and retain proheparanase in the extracellular medium.
      Tissue specificity Highly expressed in placenta and spleen and weakly expressed in lymph node, thymus, peripheral blood leukocytes, bone marrow, endothelial cells, fetal liver and tumor tissues.
      Isotype IgG
      Purification Affinity purification
      Conjugation Unconjugated
      Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
      Storage buffer PBS with 0.05% sodium azide, 50% glycerol, PH7.3
      Background Heparan sulfate proteoglycans are major components of the basement membrane and extracellular matrix. The protein encoded by this gene is an enzyme that cleaves heparan sulfate proteoglycans to permit cell movement through remodeling of the extracellular matrix. In addition, this cleavage can release bioactive molecules from the extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene.

      Images

      Western Blot analysis of Human transitional cell carcinoma tissue using HPSE Polyclonal Antibody at dilution of 1:100

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