Pro-inflammatory cytokine primarily involved in epithelial barrier repair,polarized T-helper 1 (Th1) cell and natural killer (NK) cell immune responses.Upon binding to IL18R1 and IL18RAP,forms a signaling ternary complex which activates NF-kappa-B,triggering synthesis of inflammatory mediators.Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells and natural killer (NK) cells.Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore.

Product Information

Synonyms	IL18, IGIF, IL-1g, IL-1F4, Interferon-gamma-inducing factor
Swissprot	Q14116
Reactivity	Human
Specificity	Detects Human IL-18 in ELISAs
Buffer	Capture Antibody:PBS with 0.04% Proclin 300, 50% glycerol, pH 7.4; Detection Antibody:PBS with 0.04% Proclin 300, 1% pro
Storage	Store at -20℃. Avoid freeze / thaw cycles.
Expiration Date	12 months

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Human IL-18 Antibody Pair Set

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Human IL-18 Antibody Pair Set

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