PDGFB Polyclonal Antibody

Uniprot : Q05028
    • polyclonal antibody-Elabscience
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    >
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience

      Catalog number:E-AB-40267

      Synonyms:Becaplermin,PDGF 2,PDGF B chain,PDGF subunit B,PDGF-2,PDGF2,Pdgfb,PDGFB,Platelet derived growth factor 2,Platelet-derived growth factor B chain,Platelet-derived growth factor beta polypeptide,Platelet-derived growth factor subunit B,Proto-oncogene c-Sis,SIS,SSV

      Size:
      • 20μL
      • 60μL
      • 120μL
      • 200μL
      Qty:
      - +
      Price: $60

      Host: Rabbit

      Reactivity: R

      Applications: IHC

      Lead Time: 7~10daysWelcome to order from local distributors.

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      Overview

      Synonyms Becaplermin,PDGF 2,PDGF B chain,PDGF subunit B,PDGF-2,PDGF2,Pdgfb,PDGFB,Platelet derived growth factor 2,Platelet-derived growth factor B chain,Platelet-derived growth factor beta polypeptide,Platelet-derived growth factor subunit B,Proto-oncogene c-Sis,SIS,SSV
      Swissprot Q05028
      Source Rabbit
      Reactivity Rat
      Immunogen Recombinant Rat Platelet-derived growth factor subunit B protein
      Application IHC(Detection kit: E-IR-R213)
      Recommended dilution IHC 1:100-1:200
      Concentration 0.83mg/mL

      Properties

      Cellular localization Endoplasmic reticulum,endoplasmic reticulum lumen,Extracellular region or secreted,extracellular matrix,extracellular region,extracellular space,Golgi apparatus,Golgi lumen,Golgi membrane,Plasma Membrane,basolateral plasma membrane,Other locations:cell surface,cytoplasm,platelet alpha granule lumen
      Tissue specificity Expressed in a distinct subpopulation of smooth muscle cells in injured arteries.
      Isotype IgG
      Purification Antigen Affinity Purification
      Conjugation Unconjugated
      Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
      Storage buffer PBS with 0.05% Proclin300, 50% glycerol, pH7.3.
      Background The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 7, at sites where this gene and that for COL1A1 are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans resulting from unregulated expression of growth factor. Two alternatively spliced transcript variants encoding different isoforms have been identified for this gene.

      Images

      Immunohistochemistry of paraffin-embedded Rat kidney using Pdgfb Polyclonal Antibody at dilution of 1:100

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