Phospho-AXL (Tyr691) Polyclonal Antibody

Uniprot : P30530
    • phospho antibody-Elabscience
    • phospho antibody-Elabscience
    • phospho antibody-Elabscience
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    >
    • phospho antibody-Elabscience
    • phospho antibody-Elabscience
    • phospho antibody-Elabscience
    • phospho antibody-Elabscience
    • phospho antibody-Elabscience
    • phospho antibody-Elabscience

      Catalog number:E-AB-21223

      Synonyms:Adhesion related kinase,AI323647,Ark,Axl,AXL oncogene,AXL receptor tyrosine kinase,AXL transforming gene,AXL transforming sequence/gene,EC 2.7.10.1,JTK11,Oncogene AXL,Tyro7,Tyrosine protein kinase receptor UFO,Tyrosine-protein kinase receptor UFO,UFO,UFO

      Size:
      • 20 μL
      • 60 μL
      • 120 μL
      • 200 μL
      Qty:
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      Price: $69

      Host: Rabbit

      Reactivity: H,M,R

      Applications: WB,IHC-p,ELISA

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      Overview

      Synonyms Adhesion related kinase,AI323647,Ark,Axl,AXL oncogene,AXL receptor tyrosine kinase,AXL transforming gene,AXL transforming sequence/gene,EC 2.7.10.1,JTK11,Oncogene AXL,Tyro7,Tyrosine protein kinase receptor UFO,Tyrosine-protein kinase receptor UFO,UFO,UFO
      Swissprot P30530
      Source Rabbit
      Reactivity Human,Mouse,Rat
      Immunogen Synthesized peptide derived from human Axl around the phosphorylation site of Tyr691
      Application WB(Detection kit: E-IR-R304),IHC-p(Detection kit: E-IR-R213),ELISA
      Recommended dilution WB 1:500-1:2000, IHC 1:100-1:300, ELISA 1:20000
      Concentration 1mg/mL
      Clonality Polyclonal

      Properties

      Cellular localization Membrane.
      Tissue specificity Highly expressed in metastatic colon tumors. Expressed in primary colon tumors. Weakly expressed in normal colon tissue.
      Isotype IgG
      Purification Affinity purification
      Conjugation Unconjugated
      Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
      Storage buffer PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
      Background The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. The encoded protein possesses an extracellular domain which is composed of two immunoglobulin-like motifs at the N-terminal, followed by two fibronectin type-III motifs. It transduces signals from the extracellular matrix into the cytoplasm by binding to the vitamin K-dependent protein growth arrest-specific 6 (Gas6). This gene may be involved in several cellular functions including growth, migration, aggregation and anti-inflammation in multiple cell types. Alternative splicing results in multiple transcript variants of this gene.AXL (AXL Receptor Tyrosine Kinase) is a Protein Coding gene. Diseases associated with AXL include Lymphocytic Choriomeningitis and Femoral Neuropathy. Among its related pathways are GPCR Pathway and RET signaling. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MERTK.

      Images

      Western Blot analysis of HuvEc cells with Phospho-Axl (Tyr691) Polyclonal Antibody at dilution of 1:500

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