Recombinant Human BCL2/Bcl-2 Protein (His Tag)

    • Recombinant Human BCL2 / Bcl-2 Protein (C-His)-Elabscience
    • Recombinant Protein-Elabscience
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    • Recombinant Human BCL2 / Bcl-2 Protein (C-His)-Elabscience
    • Recombinant Protein-Elabscience
    • Recombinant Human BCL2 / Bcl-2 Protein (C-His)-Elabscience
    • Recombinant Protein-Elabscience

      Catalog number:PKSH033761

      Synonyms:Apoptosis regulator Bcl-2; BCL2; Apoptosis Regulator Bcl-2; B-cell Lymphoma 2;PPP1R50

      Size:
      • 10μg
      • 50μg
      Qty:
      - +
      Price: $263

      Lead Time: Order now, ship in 3 daysWelcome to order from local distributors.

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      Overview

      Synonyms Apoptosis regulator Bcl-2; BCL2; Apoptosis Regulator Bcl-2; B-cell Lymphoma 2;PPP1R50
      Species Human
      Expression_host E.coli
      Sequence Met1-Asp211
      Accession P10415
      Mol_Mass 24.1 kDa
      AP_Mol_Mass 23-27 kDa
      Tag C-His

      Properties

      Purity > 95% as determined by reducing SDS-PAGE.
      Endotoxin < 1.0 EU per μg as determined by the LAL method.
      Storage Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
      Shipping This product is provided as liquid. It is shipped at frozen temperature with blue ice.Upon receipt, store it immediately at<-20°C.
      Formulation Supplied as a 0.2 μm filtered solution of 20mM HEPES, 150mM NaCl, 10%Glycerol, pH8.0.
      Reconstitution Please refer to the printed manual for detailed information.

      Background

      Bcl-2 is a member of a family of proteins that regulates outer mitochondrial membrane permeability. Bcl-2 is an antiapoptotic member that prevents release of cytochrome c from the mitochondria intermembrane space into the cytosol. Bcl-2 is present on the outer mitochondrial membrane and is also found on other membranes in some cell types. BCL-2 is localized to the outer membrane of mitochondria,where it plays an important role in promoting cellular survival and inhibiting the actions of pro-apoptotic proteins. The pro-apoptotic proteins in the BCL-2 family, including Bax and Bak, normally act on the mitochondrial membrane to promote permeabilization and release of cytochrome C and ROS, that are important signals in the apotosis cascade. These pro-apoptotic proteins are in turn activated by BH3-only proteins, and are inhibited by the function of BCL-2 and its relative BCL-Xl.

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      MSDS for ELISA ISO 9001

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