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Recombinant Human TNFR1/TNFRSF1A Protein (His & Fc Tag)(Active)

  • Cat.No.:PKSH031379

  • Expression host: HEK293 Cells

To Purchase PKSH031379

  • 50μg
  • 100μg
Price: $454


Synonyms CD120a;FPF;MS5;p55;p55-R;p60;TBP1;TNF-R;TNF-R-I;TNF-R55;TNFAR;TNFR1;TNFR1-d2;TNFR55;TNFR60
Species Human
Expression_host HEK293 Cells
Sequence Met 1-Thr 211
Accession NP_001056.1
Mol_Mass 49.3 kDa
AP_Mol_Mass 60-65 kDa
Tag C-His & Fc
Bio_Activity Measured by its ability to inhibit TNF-α-mediated cytotoxicity in L-929 mouse fibrosarcoma cells in the presence of the metabolic inhibitor actinomycin D. The ED50 for this effect is typically 2-12ng/mL in the presence of 1 ng/mL recombinant human TNF-α.


Purity > 90 % as determined by reducing SDS-PAGE.
Endotoxin level < 1.0 EU per µg as determined by the LAL method.
Storage Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping This product is provided as lyophilized powder which is shipped with ice packs.
Formulation Lyophilized from sterile PBS, pH 7.4
Reconstitution Please refer to the printed manual for detailed information.


The cluster of differentiation (CD) system is commonly used as cell markers in immunophynotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. CD120a (cluste of differentiation 120a), also known as TNFR1 / TNFRSF1A, is a member of CD family, tumor necrosis factor receptor superfamily. CD120a is one of the most primary receptors for the tumor necrosis factor-alpha. It has been shown to be localized to both plasma membrane lipid rafts and the trans golgi complex with the help of the death domain (DD). CD120a can activate the transcription factor NF-κB, mediate apoptosis, and regulate inflammation processes.

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