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Recombinant Rat Interleukin-2/IL-2 Protein (His Tag)

Uniprot : P17108
  • Cat.No.:PKSR030460

  • Expression host: HEK293 Cells

To Purchase PKSR030460

Size:
  • 10µg
  • 50µg
Price: $239
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Description

Synonyms Aldesleukin, IL 2, IL-2, IL2, IL2, Interleukin 2, Interleukin-2, Involved in regulation of T cell clonal expansion, Lymphokine, POIL2, T Cell Growth Factor, T-cell growth factor, TCGF
Species Rat
Expression_host HEK293 Cells
Sequence Ala 21-Gln 155
Accession P17108
Mol_Mass 16.3 kDa
AP_Mol_Mass 16 kDa
Tag C-His
Bio_Activity Testing in progress

Properties

Purity > 95 % as determined by reducing SDS-PAGE.
Endotoxin level Please contact us for more information.
Storage Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping This product is provided as lyophilized powder which is shipped with ice packs.
Formulation Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Reconstitution Please refer to the printed manual for detailed information.

Background

Interleukin-2(IL-2)is a O-glycosylated four α-helix bundle cytokine that has potent stimulatory activity for antigenactivated T cells. It is expressed by CD4+ and CD8+ T cells, γδ T cells, B cells, dendritic cells, and eosinophils. Mature rat IL-2 shares 66% and 73% amino acid sequence identity with human and mouse IL-2,respectively. The receptor for IL-2 consists of three subunits that are present on the cell surface in varying preformed complexes. IL-2 is a powerful immunoregulatory lymphokine produced by T-cells in response to antigenic or mitogenic stimulation. IL-2/IL-2R signaling is required for T-cell proliferation and other fundamental functions that are essential for the immune response. IL-2 stimulates growth and differentiation of B-cells, NK cells, lymphokine-activated killer cells, monocytes, macrophages and oligodendrocytes.

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