RXRA Monoclonal Antibody

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  • monoclonal antibody-Elabscience
  • monoclonal antibody-Elabscience
    • monoclonal antibody-Elabscience
    • monoclonal antibody-Elabscience
    • monoclonal antibody-Elabscience
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    • monoclonal antibody-Elabscience
    • monoclonal antibody-Elabscience
    • monoclonal antibody-Elabscience
    • monoclonal antibody-Elabscience
    • monoclonal antibody-Elabscience
    • monoclonal antibody-Elabscience

      Catalog number:E-AB-27338

      Synonyms:FLJ00280,FLJ00318,FLJ16020,FLJ16733,MGC102720,NR2B1,Nuclear receptor subfamily 2 group B member 1,OTTHUMP00000022510,Retinoic acid receptor RXR alpha,Retinoic acid receptor RXR-alpha,Retinoid X nuclear receptor alpha,Retinoid X receptor alpha,RXR alpha1,Rxra,RXRA,RXRalpha1

      Size:
      • 60μL
      • 120μL
      • 200μL
      Qty:
      - +
      Price: $185

      Host: Mouse

      Reactivity: H,M

      Applications: WB,ELISA

      Lead Time: 7~10 daysWelcome to order from local distributors.

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      Overview

      Synonyms FLJ00280,FLJ00318,FLJ16020,FLJ16733,MGC102720,NR2B1,Nuclear receptor subfamily 2 group B member 1,OTTHUMP00000022510,Retinoic acid receptor RXR alpha,Retinoic acid receptor RXR-alpha,Retinoid X nuclear receptor alpha,Retinoid X receptor alpha,RXR alpha1,Rxra,RXRA,RXRalpha1
      Swissprot P19793
      Source Mouse
      Reactivity Human,Mouse
      Immunogen Fusion protein of RXRA
      Application WB,ELISA
      Recommended dilution WB 1:200-1:1000
      Clonality Monoclonal

      Properties

      Clone No Clone:802
      Isotype IgG1
      Purification Protein G purification
      Conjugation Unconjugated
      Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
      Storage buffer PBS with 0.02% sodium azide, 50% glycerol, PH7.3
      Background Retinoid X receptor alpha (RXRA). Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands,all-trans or 9-cis retinoic acid,and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid. RXRA serves as a common heterodimeric partner for a number of nuclear receptors. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand,the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation,chromatin condensation and transcriptional suppression. On ligand binding,the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. The RXRA/PPARA heterodimer is required for PPARA transcriptional activity on fatty acid oxidation genes such as ACOX1 and the P450 system genes.

      Images

      Western Blot analysis of HeLa cells using RXRA Monoclonal Antibody at dilution of 1:100

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