Survivin Polyclonal Antibody

Uniprot : O15392
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    <
    >
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience

      Catalog number:E-AB-14381

      Synonyms:API4,Apoptosis inhibitor 4,Apoptosis inhibitor survivin,Apoptosis inhibitor4,Baculoviral IAP repeat containing 5,Baculoviral IAP repeat containing protein 5,Baculoviral IAP repeat-containing protein 5,BIRC 5,BIRC5,BIRC5,EPR 1,IAP4,Survivin variant 3 alpha,SVV,TIAP

      Size:
      • 20μL
      • 60μL
      • 120μL
      • 200μL
      Qty:
      - +
      Price: $69

      Host: Rabbit

      Reactivity: H,M,R

      Applications: WB,ELISA

      Lead Time: 7~10 daysWelcome to order from local distributors.

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      Overview

      Synonyms API4,Apoptosis inhibitor 4,Apoptosis inhibitor survivin,Apoptosis inhibitor4,Baculoviral IAP repeat containing 5,Baculoviral IAP repeat containing protein 5,Baculoviral IAP repeat-containing protein 5,BIRC 5,BIRC5,BIRC5,EPR 1,IAP4,Survivin variant 3 alpha,SVV,TIAP
      Swissprot O15392
      Source Rabbit
      Reactivity Human,Mouse,Rat
      Immunogen Recombinant protein of human Survivin
      Application WB(Detection kit: E-IR-R304),ELISA
      Recommended dilution WB 1:500-1:2000
      Concentration 0.2 mg/mL
      Clonality Polyclonal

      Properties

      Cellular localization Cytoplasm. Nucleus. Chromosome. Chromosome>centromere. Cytoplasm>cytoskeleton>spindle. Localizes on chromosome arms and inner centromeres from prophase through metaphase and then transferring to the spindle midzone and midbody from anaphase through cytokinesis. Colocalizes with AURKB at mitotic chromosomes.
      Tissue specificity Expressed only in fetal kidney and liver, and to lesser extent, lung and brain. Abundantly expressed in adenocarcinoma (lung, pancreas, colon, breast, and prostate) and in high-grade lymphomas. Also expressed in various renal cell carcinoma cell lines.
      Isotype IgG
      Purification Affinity purification
      Conjugation Unconjugated
      Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
      Storage buffer PBS with 0.05% sodium azide and 50% glycerol, PH7.4
      Background This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. Gene expression is high during fetal development and in most tumors, yet low in adult tissues. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

      Images

      Western Blot analysis of A431, Jurkat and hela cell using Survivin Polyclonal Antibody at dilution of 1:400

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