USP2 Polyclonal Antibody

Uniprot : O75604
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
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    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience

      Catalog number:E-AB-14653

      Synonyms:41 kDa ubiquitin specific protease,41 kDa ubiquitin-specific protease,Deubiquitinating enzyme 2,Ubiquitin carboxyl terminal hydrolase 2,Ubiquitin carboxyl-terminal hydrolase 2,ubiquitin specific peptidase 2,Ubiquitin specific processing protease 2,Ubiquitin specific protease 12,Ubiquitin specific protease 9,Ubiquitin specific protease,41kD,Ubiquitin thioesterase 2,Ubiquitin thiolesterase 2,Ubiquitin-specific-processing protease 2,Ubiquitin-specific-processing protease testis,UBP-t,UBP2,UBP41,USP2,USP9

      Size:
      • 20μL
      • 60μL
      • 120μL
      • 200μL
      Qty:
      - +
      Price: $69

      Host: Rabbit

      Reactivity: H,M,R

      Applications: IHC,ELISA

      Lead Time: 7~10 daysWelcome to order from local distributors.

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      Overview

      Synonyms 41 kDa ubiquitin specific protease,41 kDa ubiquitin-specific protease,Deubiquitinating enzyme 2,Ubiquitin carboxyl terminal hydrolase 2,Ubiquitin carboxyl-terminal hydrolase 2,ubiquitin specific peptidase 2,Ubiquitin specific processing protease 2,Ubiquitin specific protease 12,Ubiquitin specific protease 9,Ubiquitin specific protease,41kD,Ubiquitin thioesterase 2,Ubiquitin thiolesterase 2,Ubiquitin-specific-processing protease 2,Ubiquitin-specific-processing protease testis,UBP-t,UBP2,UBP41,USP2,USP9
      Swissprot O75604
      Source Rabbit
      Reactivity Human,Mouse,Rat
      Immunogen Recombinant protein of human USP2
      Application IHC(Detection kit: E-IR-R213),ELISA
      Recommended dilution IHC 1:25-1:100
      Concentration 0.3 mg/mL
      Clonality Polyclonal

      Properties

      Cellular localization Nucleus and Cytoplasm. Cytoplasm>perinuclear region. Localizes in the spermatid head in late-elongating spermatids in the thin area between the outer acrosomal membrane and the plasma membrane.
      Tissue specificity Expressed in mesangial cells of the kidney and in different types of glomerulonephritides (at protein level).
      Isotype IgG
      Purification Affinity purification
      Conjugation Unconjugated
      Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
      Storage buffer PBS with 0.05% sodium azide and 50% glycerol, PH7.4
      Background This gene encodes a member of the family of de-ubiquitinating enzymes, which belongs to the peptidase C19 superfamily. The encoded protein is a ubiquitin-specific protease which is required for TNF-alpha (tumor necrosis factor alpha) -induced NF-kB (nuclear factor kB) signaling. This protein deubiquitinates polyubiquitinated target proteins such as fatty acid synthase, murine double minute 2 (MDM2), MDM4/MDMX and cyclin D1. MDM2 and MDM4 are negative regulators of the p53 tumor suppressor and cyclin D1 is required for cell cycle G1/S transition. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.

      Images

      Immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using USP2 Polyclonal Antibody at dilution 1:30

      Immunohistochemistry of paraffin-embedded Human cervical cancer tissue using USP2 Polyclonal Antibody at dilution 1:30

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