Alternate Names	Tumor necrosis factor receptor superfamily member 1B,Tnfrsf1b,Tumor necrosis factor receptor 2,TNF-R2,TNF-RII,TNFR-II,p75,p80 TNF-alpha receptor,CD120b
Swissprot	P25119
References	1. Aggarwal BB, et al. 1985. Nature 318 665. 2. Chan FKM, et al. 2000. Science 288:2351. 3. Loetscher H, et al. 1990. Cell 61:351. 4. Rothe J, et al. 1993. Nature 364:798.

Product Details

Form	Liquid
Clone No.	TR75-54.7(See Other Available Formats)
Host	Armenian Hamster
Isotype	Armenian Hamster IgG
Isotype Control	Biotin Armenian Hamster IgG Isotype Control[PIP] [Product E-AB-F09853B]
Reactivity	Mouse
Application	FCM (See the Application Description)
Storage Buffer	Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Recommended Use	Each lot of this antibody is quality control tested by flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per 10⁶ cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Shipping	Biological ice pack at 4℃
Stability & Storage	Keep as concentrated solution. Store at 2~8°C. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Conjugation	Biotin

How to select the appropriate detection channel through the spectrogram?

Background

CD120b is a 75 kD type I transmembrane protein, also known as Tumor Necrosis Factor Receptor Type II (TNFRII) or p75. It is expressed on a variety of cells at low levels; the expression is upregulated upon activation. This receptor binds both TNF-α and LT-α (also known as TNF-β). In association with TRAF1 and TRAF2, the receptor crosslinking induced by TNF-α or LT-α trimers is critical for signal transduction, leading to apoptosis, NF-kB activation, increased expression of proinflammatory genes, tumor necrosis, and cell differentiation depending on cell type and differentiation state.

Protocols & Troubleshootings

Related Protocols	Staining Cell Surface Targets for Flow Cytometry
Troubleshooting	Troubleshooting for Flow Cytometry

Alternative Formats

Product Name	Sizes	Price
AF/LE Purified Anti-Mouse CD120b/TNFR2 Antibody[TR75-54.7]	50μg, 500μg, 1mg	Check More
Purified Anti-Mouse CD120b/TNFR2 Antibody[TR75-54.7]	25μg, 100μg	Check More

Citations

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