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Cat.No.:E-AB-F1199B
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Alternate Names | Interleukin-17A,IL-17,IL-17A,Cytotoxic T-lymphocyte-associated antigen 8,CTLA-8,CTLA8 |
Swissprot | Q62386 |
Gene ID | 16171 |
References |
1. Fitzgerald K, et al. Eds. 2001. The Cytokine FactsBook. Academic Press San Diego.
2. Numasaki M, et al. 2002. Blood 101:2620. 3. Fossiez F, et al. 1996. J. Exp. Med. 183:2593. 4. Yao Z, et al. 1997. Cytokine 9:794. 5. Dong C. 2006. Nat. Rev. Immunol. 6:329. 6. Hofstetter HH, et al. 2005 Cell. Immunol. 237:123. |
Form | Liquid |
Clone No. | TC11-18H10.1(See Other Available Formats) |
Host | Rat |
Isotype | Rat IgG1, κ |
Isotype Control | Biotin Rat IgG1, κ Isotype Control[HRPN] [Product E-AB-F09823B] |
Reactivity | Mouse |
Application | ICFCM (See the Application Description) |
Storage Buffer | Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant. |
Recommended Use | Each lot of this antibody is quality control tested by flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per 106 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application. |
Shipping | Biological ice pack at 4℃ |
Stability & Storage | Keep as concentrated solution. Store at 2~8°C. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase. |
Conjugation | Biotin |
How to select the appropriate detection channel through the spectrogram?
IL-17, also known as CTLA-8, is a T cell-expressed pleiotropic cytokine that exhibits a high degree of homology to a protein encoded by the ORF13 gene of herpes virus Saimiri. IL-17 is produced by Th cells (Th17) that are distinct from the traditional Th1- and Th2-cell subsets. IL-23 plays an important role in triggering IL-17 production. Both recombinant and natural IL-17 have been shown to exist as disulfide linked homodimers. IL-17 exhibits multiple biological activities on a variety of cells including: the induction of IL-6 and IL-8 production in fibroblasts, activation of NF-κB, and costimulation of T cell proliferation. IL-17 is an essential inflammatory mediator in the development of autoimmune diseases. Neutralization of IL-17 with monoclonal antibody is able to ameliorate the disease course. |
Related Protocols | Staining Intracellular Antigens for Flow Cytometry |
Troubleshooting |
Product Name | Sizes | Price |
FITC Anti-Mouse IL-17A Antibody[TC11-18H10.1] | 50Tests, 100Tests, 100Tests×2 | Check More |
PE Anti-Mouse IL-17A Antibody[TC11-18H10.1] | 50Tests, 100Tests, 100Tests×2 | Check More |
APC Anti-Mouse IL-17A Antibody[TC11-18H10.1] | 50Tests, 100Tests, 100Tests×2 | Check More |
Elab Fluor® 647 Anti-Mouse IL-17A Antibody[TC11-18H10.1] | 50Tests, 100Tests, 100Tests×2 | Check More |
FITC Anti-Mouse IL-17A Antibody[TC11-18H10.1] | 25μg, 100μg | Check More |
PE Anti-Mouse IL-17A Antibody[TC11-18H10.1] | 25μg, 100μg | Check More |
APC Anti-Mouse IL-17A Antibody[TC11-18H10.1] | 25μg, 100μg | Check More |
Elab Fluor® 647 Anti-Mouse IL-17A Antibody[TC11-18H10.1] | 25μg, 100μg | Check More |