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Cat.No.:E-AB-F1254M
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Alternate Names | LAMP-1,Lysosome-associated membrane glycoprotein 1, lysosomal membrane glycoprotein 1, CD107 antigen-like family member A, lysosome-associated membrane protein 1 |
Swissprot | P11438 |
Gene ID | 16783 |
References |
1.Arterburn LM, Earles BJ, August JT. The disulfide structure of Arterburn LM, Earles BJ, August JT. The disulfide structure ofmouse lysosome-associated membrane protein 1. J Biol Chem. 1990; 265(13):7419-7423. (Biology).
2.Chen JW, Chen GL, D'Souza MP, Murphy TL, August JT. Lysosomal membrane glycoproteins: 3.properties of LAMP-1 and LAMP-2. Biochem Soc Symp. 1986; 51:97-112. (Biology). Chen JW, Murphy TL, Willingham MC, Pastan I, August JT. Identification of two lysosomal membrane glycoproteins. J Cell Biol. 1985; 101(1):85-95. (Biology). |
Form | Liquid |
Clone No. | 1D4B(See Other Available Formats) |
Host | Rat |
Isotype | Rat IgG2a, κ |
Isotype Control | Elab Fluor® 647 Rat IgG2a, κ Isotype Control[2A3] [Product E-AB-F09832M] |
Reactivity | Mouse |
Application | FCM/ICFCM (See the Application Description) |
Storage Buffer | Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant. |
Recommended Use | Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. |
Shipping | Biological ice pack at 4℃ |
Stability & Storage | Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase. |
Conjugation | Elab Fluor® 647 |
Elab Fluor® 647 is designed to be excited by the Red laser (627-640 nm) and detected using an optical filter centered near 670 nm (e.g., a 660/20 nm bandpass filter). | |
How to select the appropriate detection channel through the spectrogram?
The 1D4B antibody recognizes CD107a which is also known as, Lysosome-Associated Membrane Protein 1 (LAMP-1). CD107a is one of the two major glycoproteins in lysosome membranes that provide useful markers to distinguish lysosomes from other organelles. CD107a may play a role in the lysosomal degradation of certain molecules. Mouse CD107a is a type I transmembrane glycoprotein. It consists of a 40-kDa core protein which is heavily glycosylated to form heterogeneous mature glycoprotein of 110-140 kDa. It is principally expressed in epithelial cells and macrophages in a variety of organs. Following activation, CD107a is relocated to the surface of some lymphocytes, macrophages, epithelial cells, endothelial cells, platelets, and tumor cells. Cell-surface CD107a may participate in intercellular adhesion and adhesion to the extracellular matrix. Cell surface CD107a expression can serve as a useful marker for cytotoxic NK and CD8+ T cells, as well as, some malignant tumor cells. |
Related Protocols | Staining Cell Surface Targets for Flow Cytometry |
Troubleshooting |
Product Name | Sizes | Price |
FITC Anti-Mouse CD107a/LAMP-1 Antibody[1D4B] | 50Tests, 100Tests, 100Tests×2 | Check More |
PE Anti-Mouse CD107a/LAMP-1 Antibody[1D4B] | 50Tests, 100Tests, 100Tests×2 | Check More |
APC Anti-Mouse CD107a/LAMP-1 Antibody[1D4B] | 50Tests, 100Tests, 100Tests×2 | Check More |
PE/Cyanine5 Anti-Mouse CD107a/LAMP-1 Antibody[1D4B] | 50Tests, 100Tests, 100Tests×2 | Check More |
PE/Cyanine7 Anti-Mouse CD107a/LAMP-1 Antibody[1D4B] | 50Tests, 100Tests, 100Tests×2 | Check More |
PE/Cyanine5.5 Anti-Mouse CD107a/LAMP-1 Antibody[1D4B] | 50Tests, 100Tests, 100Tests×2 | Check More |
PerCP/Cyanine5.5 Anti-Mouse CD107a/LAMP-1 Antibody[1D4B] | 50Tests, 100Tests, 100Tests×2 | Check More |
Elab Fluor® 488 Anti-Mouse CD107a/LAMP-1 Antibody[1D4B] | 50Tests, 100Tests, 100Tests×2 | Check More |
PE/Elab Fluor® 594 Anti-Mouse CD107a/LAMP-1 Antibody[1D4B] | 50Tests, 100Tests, 100Tests×2 | Check More |
Elab Fluor® Violet 450 Anti-Mouse CD107a/LAMP-1 Antibody[1D4B] | 50Tests, 100Tests, 100Tests×2 | Check More |