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Mouse IL-18(Interleukin 18) ELISA Kit

Citations(73)Uniprot : P70380

  • Cat.No.:E-EL-M0730

  • Reactivity: Mouse
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Manual MSDS

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Size:
  • 96T
  • 48T
  • 24T
  • 96T*5
  • 96T*10
Price: $609
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Product Details

Properties

Assay type Sandwich-ELISA
Format 96T/48T
Assay time 3.5h
Detection range 15.63-1000 pg/mL
Sensitivity 9.38 pg/mL
Sample type &Sample volume serum, plasma and other biological fluids; 100μL
Specificity This kit recognizes Mouse IL-18 in samples. No significant cross-reactivity or interference between Mouse IL-18 and analogues was observed.
Reproducibility Both intra-CV and inter-CV are < 10%.
Application This ELISA kit applies to the in vitro quantitative determination of Mouse IL-18 concentrations in serum, plasma and other biological fluids.

Test Principle

This ELISA kit uses the Sandwich-ELISA principle. The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to Mouse IL-18. Standards or samples are added to the micro ELISA plate wells and combined with the specific antibody. Then a biotinylated detection antibody specific for Mouse IL-18 and Avidin-Horseradish Peroxidase (HRP) conjugate are added successively to each micro plate well and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain Mouse IL-18, biotinylated detection antibody and Avidin-HRP conjugate will appear blue in color. The enzyme-substrate reaction is terminated by the addition of stop solution and the color turns yellow. The optical density (OD) is measured spectrophotometrically at a wavelength of 450 nm ± 2 nm. The OD value is proportional to the concentration of Mouse IL-18. You can calculate the concentration of Mouse IL-18 in the samples by comparing the OD of the samples to the standard curve.

Kit components & Storage

An unopened kit can be stored at 2-8℃ for 1 month. If the kit is not supposed to be used within 1 month, store the components separately according to the following conditions once the kit is received.
ItemSpecificationsStorage
Micro ELISA Plate(Dismountable) 96T: 8 wells ×12 strips
48T: 8 wells ×6 strips 		-20℃, 6 months
Reference Standard 96T: 2 vials
48T: 1 vial
Concentrated Biotinylated Detection Ab (100×) 96T: 1 vial, 120 μL
48T: 1 vial, 60 μL
Concentrated HRP Conjugate (100×) 96T: 1 vial, 120 μL
48T: 1 vial, 60 μL 		-20℃(Protect from light), 6 months
Reference Standard & Sample Diluent 1 vial, 20 mL 2-8°C, 6 months
Biotinylated Detection Ab Diluent 1 vial, 14 mL
HRP Conjugate Diluent 1 vial, 14 mL
Concentrated Wash Buffer (25×) 1 vial, 30 mL
Substrate Reagent 1 vial, 10 mL 2-8℃(Protect from light)
Stop Solution 1 vial, 10 mL 2-8°C
Plate Sealer 5 pieces
Manual 1 copy
Certificate of Analysis 1 copy

Technical Data

Precision

Intra-assay Precision (Precision within an assay): 3 samples with low, mid range and high level Mouse IL-18 were tested 20 times on one plate, respectively.
Inter-assay Precision (Precision between assays): 3 samples with low, mid range and high level Mouse IL-18 were tested on 3 different plates, 20 replicates in each plate.

  Intra-assay Precision Inter-assay Precision
Sample 1 2 3 1 2 3
n 20 20 20 20 20 20
Mean (pg/mL) 49.50 145.20 342.80 53.00 144.60 363.40
Standard deviation 2.60 8.10 16.80 3.70 7.40 12.40
CV (%) 5.25 5.58 4.90 6.98 5.12 3.41

Recovery

The recovery of Mouse IL-18 spiked at three different levels in samples throughout the range of the assay was evaluated in various matrices.

Sample Type Range (%) Average Recovery (%)
Serum(n=8) 91-102 97
EDTA plasma (n=8) 86-100 91
Cell culture media (n=8) 92-104 99

Linearity

Samples were spiked with high concentrations of Mouse IL-18 and diluted with Reference Standard & Sample Diluent to produce samples with values within the range of the assay.

Target Information

Database LinksSwissProt:   P70380
SynonymsIL18, IGIF, IL-1g, IL-1F4, Interferon-gamma-inducing factor
Research AreaCancer, Metabolism, Immunology

Assay Procedures

elisa assay procedure 1

1. Add 100μL standard or sample to the wells. Incubate for 90 min at 37°C
elisa assay procedure 2

2. Discard the liquid, immediately add 100μL Biotinylated Detection Ab working solution to each well. Incubate for 60 min at 37°C
elisa assay procedure 3

3. Aspirate and wash the plate for 3 times
elisa assay procedure 4

4. Add 100μL HRP conjugate working solution. Incubate for 30 min at 37°C. Aspirate and wash the plate for 5 times
elisa assay procedure 5

5. Add 90μL Substrate Reagent. Incubate for 15 min at 37°C
elisa assay procedure 6

6. Add 50μL Stop Solution
elisa assay procedure 7

7. Read the plate at 450nm immediately. Calculation of the results

Citations

  1. Arthritis & Rheumatology (2022) IF: 15.483
    NLRP3 attenuates intraocular inflammation by inhibiting AIM2 mediated pyroptosis through the P-SIK1/SREBF1 pathway

    DOI: 10.1002/art.42420
    Sample: BMDMs
  2. JOURNAL OF PINEAL RESEARCH (2023) IF: 12.081
    Melatonin inhibits atherosclerosis progression via Galectin-3 downregulation to enhance autophagy and inhibit inflammation

    DOI: 10.1111/jpi.12855
    Sample: serum
  3. Engineering (2022) IF: 12.834
    CPAL, as a New Mediator of Cardiomyocyte Metabolic Alterations and Pyroptosis, Regulates Myocardial Infarction Injury in Mice

    DOI: 10.1016/j.eng.2022.08.012
    Sample: serum
  4. BRITISH JOURNAL OF PHARMACOLOGY (2023) IF: 9.4730
    Microsomal prostaglandin E synthase-1 inhibition prevents adverse cardiac remodeling after myocardial infarction in mice

    DOI: 10.1111/bph.16061
    Sample: Plasma
  5. Cell Death & Disease (2020) IF: 8.4689
    Inhibition of the NLRP3-inflammasome prevents cognitive deficits in experimental autoimmune encephalomyelitis mice via the alteration of astrocyte phenotype

    DOI: 10.1038/s41419-020-2565-2

    PMID: 32415059

    		 Sample: Tissue homogenate
  6. Cellular and Molecular Gastroenterology and Hepatology (2022) IF: 8.7970
    Klebsiella pneumoniae induces inflammatory bowel disease through caspase-11-mediated IL-18 in the gut epithelial cells

    DOI: 10.1016/j.jcmgh.2022.11.005
    Sample: colon tissue
  7. Acta Biomaterialia (2021) IF: 8.9469
    Sialic acid conjugate-modified liposomes enable tumor homing of epirubicin via neutrophil/monocyte infiltration for tumor therapy

    DOI: 10.1016/j.actbio.2021.07.063

    PMID: 34339869

    		 Sample: S180 cell-Xenograft
  8. PHARMACOLOGICAL RESEARCH (2021) IF: 7.658
    Microglial TLR4-induced TAK1 phosphorylation and NLRP3 activation mediates neuroinflammation and contributes to chronic morphine-induced antinociceptive tolerance

    DOI: 10.1016/j.phrs.2021.105482

    PMID: 33549727

    		 Sample: Cerebrospinal Fluid
  9. Cells (2022) IF: 7.666
    S100A8-Mediated NLRP3 Inflammasome-Dependent Pyroptosis in Macrophages Facilitates Liver Fibrosis Progression

    DOI: 10.3390/cells11223579
    Sample: serum
  10. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023) IF: 6.208
    The Mechanism of Two Benzaldehydes from Aspergillus terreus C23-3 Improve Neuroinflammatory and Neuronal Damage to Delay the Progression of Alzheimer’s Disease

    DOI: 10.3390/ijms24020905
    Sample: BV-2 cell
  11. Cell Death & Disease (2020) IF: 6.304
    GDF11 inhibits cardiomyocyte pyroptosis and exerts cardioprotection in acute myocardial infarction mice by upregulation of transcription factor HOXA3

    DOI: 10.1038/s41419-020-03120-6

    PMID: 33100331

    		 Sample: Serum
  12. BIOMEDICINE & PHARMACOTHERAPY (2018) IF: 6.53
    Jinxin oral liquid inhibits human respiratory syncytial virus-induced excessive inflammation associated with blockade of the NLRP3/ASC/Caspase-1 pathway

    DOI: 10.1016/j.biopha.2018.04.174
    Sample: Serum,Tissue homogenate
  13. PHYTOMEDICINE (2022) IF: 6.656
    Treatment of ulcerative colitis with Wu-Mei-Wan by inhibiting intestinal inflammatory response and repairing damaged intestinal mucosa

    DOI: 10.1016/j.phymed.2022.154362

    PMID: 35947900

    		 Sample: serum
  14. PHYTOMEDICINE (2022) IF: 6.656
    Shexiang Baoxin Pill attenuates myocardial ischemia/reperfusion injury by activating autophagy via modulating the ceRNA-Map3k8 pathway

    DOI: 10.1016/j.phymed.2022.154336

    PMID: 35849969

    		 Sample: serum,primary cardiomyocytes
  15. CELL BIOLOGY AND TOXICOLOGY (2023) IF: 6.819
    Syringaresinol protects against diabetic nephropathy by inhibiting pyroptosis via NRF2-mediated antioxidant pathway

    DOI: 10.1007/s10565-023-09790-0
    Sample: serum,Primary renal tubular epithelial cells (RTEC
  16. INFLAMMOPHARMACOLOGY (2022) IF: 5.093
    Nebivolol elicits a neuroprotective effect in the cuprizone model of multiple sclerosis in mice: emphasis on M1/M2 polarization and inhibition of NLRP3 inflammasome activation

    DOI: 10.1007/s10787-022-01045-4

    PMID: 35948811

    		 Sample: brain
  17. EUROPEAN JOURNAL OF PHARMACOLOGY (2022) IF: 5.195
    The selective NLRP3 inflammasome inhibitor MCC950 improves isoproterenol-induced cardiac dysfunction by inhibiting cardiomyocyte senescence

    DOI: 10.1016/j.ejphar.2022.175364
    Sample: serum
  18. EUROPEAN JOURNAL OF PHARMACOLOGY (2022) IF: 5.195
    Anesthetic sevoflurane simultaneously regulates autophagic flux and pyroptotic cell death-associated cellular inflammation in the hypoxic/re-oxygenated cardiomyocytes: Identification of sevoflurane as putative drug for the treatment of myocardial ischemia

    DOI: 10.1016/j.ejphar.2022.175363

    PMID: 36343694

    		 Sample: serum,myocardial tissue
  19. Cell Death Discovery (2019) IF: 5.241
    Celastrol attenuates ox-LDL-induced mesangial cell proliferation via suppressing NLRP3 inflammasome activation

    DOI: 10.1038/s41420-019-0196-0
    Sample: MCs cells
  20. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2017) IF: 5.476
    A novel mechanism of diabetic vascular endothelial dysfunction: Hypoadiponectinemia-induced NLRP3 inflammasome activation

    DOI: 10.1016/j.bbadis.2017.02.012
    Sample: Serum,Cell culture supernatant
  21. Journal of Ginseng Research (2020) IF: 5.487
    Inhibitory activity of gintonin on inflammation in human IL-1β-stimulated fibroblast-like synoviocytes and collagen-induced arthritis in mice

    DOI: 10.1016/j.jgr.2020.12.001

    PMID: 34295211

    		 Sample: serum
  22. MOLECULAR NEUROBIOLOGY (2022) IF: 5.682
    LncRNA Tug1 Contributes Post-stroke NLRP3 Inflammasome-Dependent Pyroptosis via miR-145a-5p/Tlr4 Axis

    DOI: 10.1007/s12035-022-03000-4

    PMID: 35989413

    		 Sample: serum,BV-2 cell
  23. INTERNATIONAL IMMUNOPHARMACOLOGY (2022) IF: 5.714
    Targeting PERK mediated endoplasmic reticulum stress attenuates neuroinflammation and alleviates lipopolysaccharide-induced depressive-like behavior in male mice

    DOI: 10.1016/j.intimp.2022.109092

    PMID: 35940075

    		 Sample: plasma
  24. INTERNATIONAL IMMUNOPHARMACOLOGY (2022) IF: 5.714
    Edaravone dexborneol provides neuroprotective benefits by suppressing NLRP3 inflammasome-induced microglial pyroptosis in experimental ischemic stroke

    DOI: 10.1016/j.intimp.2022.109315

    PMID: 36279668

    		 Sample: brain tissue
  25. Nutrients (2022) IF: 5.719
    Procyanidin B2 Attenuates Nicotine-Induced Hepatocyte Pyroptosis through a PPARγ-Dependent Mechanism

    DOI: 10.3390/nu14091756
    Sample: serums,hepatocytes
  26. Frontiers in Aging Neuroscience (2022) IF: 5.75
    Salidroside Ameliorates Alzheimer's Disease by Targeting NLRP3 Inflammasome-Mediated Pyroptosis

    DOI: 10.3389/fnagi.2021.809433
    Sample: brain tissue,PC12 cell
  27. CELL PROLIFERATION (2020) IF: 5.753
    TNF‐α/HMGB1 inflammation signalling pathway regulates pyroptosis during liver failure and acute kidney injury

    DOI: 10.1111/cpr.12829
    Sample: serum
  28. Frontiers in Pharmacology (2021) IF: 5.811
    Ethyl 2-Succinate-Anthraquinone Attenuates Inflammatory Response and Oxidative Stress via Regulating NLRP3 Signaling Pathway.

    DOI: 10.3389/fphar.2021.719822
    Sample: blood
  29. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021) IF: 5.924
    Terazosin Stimulates Pgk1 to Remedy Gastrointestinal Disorders

    DOI: 10.3390/ijms23010416

    PMID: 35008842

    		 Sample: colon tissue
  30. ANTIVIRAL RESEARCH (2019) IF: 5.97
    N-Acetyl cysteine effectively alleviates Coxsackievirus B-Induced myocarditis through suppressing viral replication and inflammatory response

    DOI: 10.1016/j.antiviral.2019.104699
    Sample: heart
  31. Frontiers in Pharmacology (2022) IF: 5.988
    Resveratrol activates CD8+ T cells through IL-18 bystander activation in lung adenocarcinoma.

    DOI: 10.3389/fphar.2022.1031438
    Sample: RAW264.7 cells
  32. ENVIRONMENTAL TOXICOLOGY (2021) IF: 4.119
    Effects of 2,4-dichlorophenoxyacetic acid on the expression of NLRP3 inflammasome and autophagy-related proteins as well as the protective effect of Lycium barbarum polysaccharide in neonatal rats

    DOI: 10.1002/tox.23358

    PMID: 34464015

    		 Sample: BV2 cell
  33. ENVIRONMENTAL TOXICOLOGY (2022) IF: 4.119
    C1q/tumor necrosis factor-related protein 9 protects cultured chondrocytes from IL-1β-induced inflammatory injury by inhibiting NLRP3 inflammasome activation via the AdipoR1/AMPK axis

    DOI: 10.1002/tox.23452

    PMID: 34990072

    		 Sample: chondrocytes
  34. ENVIRONMENTAL TOXICOLOGY (2022) IF: 4.119
    2,4-dichlorophenoxyacetic acid induces ROS activation in NLRP3 inflammatory body-induced autophagy disorder in microglia and the protective effect of Lycium barbarum polysaccharide

    DOI: 10.1002/tox.23471

    PMID: 35099110

    		 Sample: BV2 cell
  35. Frontiers in Cellular and Infection Microbiology (2020) IF: 4.123
    Extracellular Histone H3 Induces Pyroptosis During Sepsis and May Act Through NOD2 and VSIG4/NLRP3 Pathways

    DOI: 10.3389/fcimb.2020.00196

    PMID: 32432055

    		 Sample: Cell culture supernatant
  36. MOLECULES (2022) IF: 4.412
    Eriodictyol and Homoeriodictyol Improve Memory Impairment in Aβ25–35-Induced Mice by Inhibiting the NLRP3 Inflammasome

    DOI: 10.3390/molecules27082488
    Sample: brain
  37. ACS Chemical Neuroscience (2020) IF: 4.486
    Autophagy Activation Represses Pyroptosis through the IL-13 and JAK1/STAT1 Pathways in a Mouse Model of Moderate Traumatic Brain Injury

    DOI: 10.1021/acschemneuro.0c00517

    PMID: 33170612

    		 Sample: Plasma
  38. Frontiers in Immunology (2019) IF: 4.716
    Mechanistic Insight Into the Activation of the NLRP3 Inflammasome by Neisseria gonorrhoeae in Macrophages

    DOI: 10.3389/fimmu.2019.01815
    Sample: J774A.1 cells
  39. Journal of Immunology Research (2022) IF: 4.818
    The Proinflammatory Cytokines IL-18, IL-21, and IFN-γ Differentially Regulate Liver Inflammation and Anti-Mitochondrial Antibody Level in a Murine Model of Primary Biliary Cholangitis

    DOI: 10.1155/2022/7111445
    Sample: Sera
  40. Aging-US (2020) IF: 4.831
    Salidroside ameliorates Parkinson's disease by inhibiting NLRP3-dependent pyroptosis

    DOI: 10.18632/aging.103215

    PMID: 32432571

    		 Sample: Cell culture supernatant,Tissue homogenate
  41. Aging-US (2020) IF: 4.831
    Lipopolysaccharide upregulates miR-132/212 in Hirschsprung-associated enterocolitis, facilitating pyroptosis by activating NLRP3 inflammasome via targeting Sirtuin 1 (SIRT1)

    DOI: 10.18632/aging.103852

    PMID: 32950974

    		 Sample: Serum
  42. INTERNATIONAL IMMUNOPHARMACOLOGY (2021) IF: 4.932
    Role of vitamin D/VDR nuclear translocation in down-regulation of NF-κB/NLRP3/caspase-1 axis in lupus nephritis

    DOI: 10.1016/j.intimp.2021.108131

    PMID: 34536747

    		 Sample: serum,Mouse renal tubular epithelial cells (mRTECs
  43. INTERNATIONAL IMMUNOPHARMACOLOGY (2021) IF: 4.932
    Protective effect of combination of anakinra and MCC950 against acute lung injury is achieved through suppression of the NF-κB-mediated-MAPK and NLRP3-caspase pathways

    DOI: 10.1016/j.intimp.2021.107506

    PMID: 34022766

    		 Sample: Tissue homogenate(lung),Bronchoalveolar Lavage Flu
  44. INTERNATIONAL IMMUNOPHARMACOLOGY (2020) IF: 4.932
    COX-2-PGE2 signaling pathway contributes to hippocampal neuronal injury and cognitive impairment in PTZ-kindled epilepsy mice

    DOI: 10.1016/j.intimp.2020.106801
    Sample: Tissue homogenate
  45. Scientific Reports (2022) IF: 4.996
    IL-37 alleviates Coxsackievirus B3-induced viral myocarditis via inhibiting NLRP3 inflammasome-mediated pyroptosis

    DOI: 10.1038/s41598-022-22617-y
    Sample: serum
  46. JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY (2021) IF: 3.011
    Rhamnetin ameliorates macrophage-mediated inflammation and pro-atherosclerosis pathways in apolipoprotein E-deficient mice

    DOI: 10.26402/jpp.2021.2.10
    Sample: aorta
  47. IMMUNOLOGICAL INVESTIGATIONS (2022) IF: 3.044
    Knockdown of PHLDA1 Alleviates Necrotizing Enterocolitis by Inhibiting NLRP3 Inflammasome Activation and Pyroptosis Through Enhancing Nrf2 Signaling

    DOI: 10.1080/08820139.2022.2161910
    Sample: intestinal tissues
  48. CYTOKINE (2019) IF: 3.078
    6-Gingerol attenuates macrophages pyroptosis via the inhibition of MAPK signaling pathways and predicts a good prognosis in sepsis

    DOI: 10.1016/j.cyto.2019.154854

    PMID: 31539844

    		 Sample: Cell culture supernatant
  49. PLoS One (2021) IF: 3.24
    Saffron extract attenuates neuroinflammation in rmTBI mouse model by suppressing NLRP3 inflammasome activation via SIRT1

    DOI: 10.1371/journal.pone.0257211

    PMID: 34506597

    		 Sample: brain
  50. Biomed Research International (2022) IF: 3.246
    Fluoride Exposure Suppresses Proliferation and Enhances Endoplasmic Reticulum Stress and Apoptosis Pathways in Hepatocytes by Downregulating Sirtuin-1

    DOI: 10.1155/2022/7380324

    PMID: 36046439

    		 Sample: serum
  51. Bioengineered (2021) IF: 3.269
    The protective effects of S14G-humanin (HNG) against mono-sodium urate (MSU) crystals- induced gouty arthritis

    DOI: 10.1080/21655979.2021.2001911

    PMID: 34965184

    		 Sample: BMDMs
  52. VETERINARY MICROBIOLOGY (2022) IF: 3.293
    IL-5 enhances the resistance of Actinobacillus pleuropneumoniae infection in mice through maintaining appropriate levels of lung M2, PMN-II and highly effective neutrophil extracellular traps

    DOI: 10.1016/j.vetmic.2022.109438

    PMID: 35468400

    		 Sample: Bronchoalveolar lavage fluid (BALF)
  53. INTERNATIONAL IMMUNOPHARMACOLOGY (2019) IF: 3.361
    Icariin targets Nrf2 signaling to inhibit microglia-mediated neuroinflammation

    DOI: 10.1016/j.intimp.2019.05.033
    Sample: primary microglia,BV2 cells
  54. Journal of Personalized Medicine (2022) IF: 3.508
    NLRP6 Induces Lung Injury and Inflammation Early in Brucella and Influenza Coinfection

    DOI: 10.3390/jpm12122063
    Sample: lung tissues
  55. Frontiers in Endocrinology (2018) IF: 3.519
    Verapamil Ameliorates Hepatic Metaflammation by Inhibiting Thioredoxin-Interacting Protein/NLRP3 Pathways

    DOI: 10.3389/fendo.2018.00640
    Sample: Serum
  56. BRAIN RESEARCH BULLETIN (2023) IF: 3.715
    IGF2 inhibits hippocampal over-activated microglia and alleviates depression-like behavior in LPS- treated male mice

    DOI: 10.1016/j.brainresbull.2023.01.001
    Sample: Serum
  57. BRAIN RESEARCH BULLETIN (2023) IF: 3.715
    Acetaldehyde dehydrogenase 2 activation attenuates sepsis-induced brain injury through NLRP3 inflammasome regulation

    DOI: 10.1016/j.brainresbull.2023.01.012
    Sample: HT22 cell
  58. Frontiers in Medicine (2020) IF: 3.9
    Adiponectin Inhibits NLRP3 Inflammasome Activation in Nonalcoholic Steatohepatitis via AMPK-JNK/ErK1/2-NFκB/ROS Signaling Pathways

    DOI: 10.3389/fmed.2020.546445

    PMID: 33251225

    		 Sample: Tissue homogenate(liver tissue)
  59. IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY (2019) IF: 2.086
    Pulegone inhibits inflammation via suppression of NLRP3 inflammasome and reducing cytokine production in mice

    DOI: 10.1080/08923973.2019.1588292
    Sample: serum
  60. Biomed Research International (2020) IF: 2.276
    miR-1929-3p Overexpression Alleviates Murine Cytomegalovirus-Induced Hypertensive Myocardial Remodeling by Suppressing Ednra/NLRP3 Inflammasome Activation

    DOI: 10.1155/2020/6653819

    PMID: 33457411

    		 Sample: serum,heart
  61. Neuropsychiatric Disease and Treatment (2021) IF: 2.57
    Bushen Huoxue Acupuncture Inhibits NLRP1 Inflammasome-Mediated Neuronal Pyroptosis in SAMP8 Mouse Model of Alzheimer’s Disease

    DOI: 10.2147/NDT.S279304
    Sample: Cell lysate
  62. Evidence-based Complementary and Alternative Medicine (2022) IF: 2.63
    Biejiajian Pill Ameliorates Diabetes-Associated Atherosclerosis through Inhibition of the NLRP3 Inflammasome

    DOI: 10.1155/2022/9131178

    PMID: 35692570

    		 Sample: serum
  63. BIOLOGICAL TRACE ELEMENT RESEARCH (2020) IF: 2.639
    Sodium P-aminosalicylic Acid Inhibits Manganese-Induced Neuroinflammation in BV2 Microglial Cells via NLRP3-CASP1 Inflammasome Pathway

    DOI: 10.1007/s12011-020-02471-7

    PMID: 33156491

    		 Sample: Cell sample
  64. MEDICAL SCIENCE MONITOR (2021) IF: 2.649
    Downregulating Gasdermin D Reduces Severe Acute Pancreatitis Associated with Pyroptosis

    DOI: 10.12659/MSM.927968

    PMID: 33582700

    		 Sample: Serum
  65. Evidence-based Complementary and Alternative Medicine (2022) IF: 2.65
    Fu Fang Zhen Zhu Tiao Zhi Capsules Protect against Myocardial Ischemia by Inhibiting Cardiomyocyte Pyroptosis.

    DOI: 10.1155/2022/4752360
    Sample: serum,cardiomyocyte
  66. IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL (2022) IF: 2.723
    The Berberis vulgaris L. extract berberine exerts its anti-oxidant effects to ameliorate cholesterol overloading–induced cell apoptosis in the primary mice hepatocytes: an in vitro study

    DOI: 10.1007/s11626-022-00737-z
    Sample: serum
  67. EUROPEAN JOURNAL OF PHARMACOLOGY (2016) IF: 2.73
    Liraglutide attenuates lipopolysaccharide-induced acute lung injury in mice

    DOI: 10.1016/j.ejphar.2016.10.016
    Sample: Bronchoalveolar Lavage Fluid
  68. REDOX REPORT (2020) IF: 2.753
    hnRNPK knockdown alleviates NLRP3 inflammasome priming by repressing FLIP expression in Raw264.7 macrophages

    DOI: 10.1080/13510002.2020.1857157

    PMID: 33269646

    		 Sample: Cell culture supernatant
  69. Frontiers in Neurology (2020) IF: 2.889
    Ablation of GSDMD Improves Outcome of Ischemic Stroke Through Blocking Canonical and Non-canonical Inflammasomes Dependent Pyroptosis in Microglia

    DOI: 10.3389/fneur.2020.577927

    PMID: 33329317

    		 Sample: BV2 cell
  70. INFLAMMATION (2019) IF: 2.939
    Sinomenine Attenuates Cartilage Degeneration by Regulating miR-223-3p/NLRP3 Inflammasome Signaling

    DOI: 10.1007/s10753-019-00986-3

    PMID: 30847744

    		 Sample: Serum,Cell culture supernatant
  71. Molecular Medicine Reports (2021) IF: 2.952
    Remote ischemic post‑conditioning alleviates ischemia/reperfusion‑induced intestinal injury via the ERK signaling pathway‑mediated RAGE/HMGB axis

    DOI: 10.3892/mmr.2021.12413

    PMID: 34490475

    		 Sample: serum
  72. BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH (2018) IF: 1.492
    NLRP3 inflammasome signaling as an early molecular response is negatively controlled by miR-186 in CFA-induced prosopalgia mice

    DOI: 10.1590/1414-431X20187602
    Sample: Serum,Tissue homogenate
  73. Molecular Medicine Reports (2018) IF: 1.922
    Embelin inhibits abdominal aortic aneurysm through decreasing IL‑6‑induced STAT3 and NF‑κB inactivation

    DOI: 10.3892/mmr.2018.9221
    Sample: Aortic tissues
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