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Recombinant 2019-nCoV Envelope Protein (His Tag)

Uniprot : QHD43418.1
  • Cat.No.:PKSR030488

  • Expression host: E.coli

To Purchase PKSR030488

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  • 1mg
Price: $880
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Description

Synonyms 2019-nCoV E protein; 2019-nCoV sM protein
Species Virus
Expression_host E.coli
Sequence Met1-Val75
Accession QHD43418.1
Mol_Mass 27.5 kDa
AP_Mol_Mass 22-25 kDa
Tag N-6His

Properties

Purity > 85 % as determined by reducing SDS-PAGE.
Endotoxin level < 1.0 EU per µg as determined by the LAL method.
Storage Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Shipping This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs.Upon receipt; store it immediately at<-20°C.
Formulation Supplied as a 0.2 μM filtered solution of 20mM Tris-HCl, 200mM NaCl, pH 8.0.
Reconstitution Please refer to the printed manual for detailed information.

Background

Coronavirus envelope (E) proteins are short (100 residues) polypeptides that contain at least one transmembrane (TM) domain and a cluster of 2-3 juxtamembrane cysteines. These proteins are involved in viral morphogenesis and tropism, and their absence leads in some cases to aberrant virions, or to viral attenuation. In common to other viroporins, coronavirus envelope proteins increase membrane permeability to ions, plays a central role in virus morphogenesis and assembly. Acts as a viroporin and self-assembles in host membranes forming pentameric protein-lipid pores that allow ion transport. Also plays a role in the induction of apoptosis. Activates the host NLRP3 inflammasome, leading to IL-1beta overproduction.

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