Recombinant 2019-nCoV Guanine-N7_meth Protein (His Tag)

    • Recombinant 2019-nCoV Guanine-N7_meth Protein (His Tag)-Elabscience
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    • Recombinant 2019-nCoV Guanine-N7_meth Protein (His Tag)-Elabscience
    • Recombinant 2019-nCoV Guanine-N7_meth Protein (His Tag)-Elabscience

      Catalog number:PKSR030473

      Synonyms:SARS-CoV 2 nsp14; SARS-CoV 2 ExoN; Guanine-N7 methyltransferase

      Size:
      • 10µg
      • 50µg
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      Price: $220

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      Overview

      Synonyms SARS-CoV 2 nsp14; SARS-CoV 2 ExoN; Guanine-N7 methyltransferase
      Species Virus
      Expression_host E.coli
      Sequence Ala1-Gln527
      Accession YP_009725309.1
      Mol_Mass 62.9 kDa
      AP_Mol_Mass 60 kDa
      Tag N-6His

      Properties

      Purity > 85 % as determined by reducing SDS-PAGE.
      Endotoxin < 1.0 EU per µg as determined by the LAL method.
      Storage Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
      Shipping This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs.Upon receipt; store it immediately at<-20°C.
      Formulation Supplied as a 0.2 μM filtered solution of PBS, 10% Glycerol, pH 7.4.
      Reconstitution Please refer to the printed manual for detailed information.

      Background

      The nonstructural protein (nsp) 14 of 2019-nCoV was identified as a cap (guanine-N7)-methyltransferase (N7-MTase). Nsp14 of coronaviruses two different activities: an exoribonuclease activity acting on both ssRNA and dsRNA in a 3' to 5' direction and a N7-guanine methyltransferase activity. It may be involved in the proof-reading ability during the viral RNA replication and transcription. GTP, dGTP as well as cap analogs GpppG, GpppA and m7GpppG could be methylated by nsp14.positive-stranded RNA genome of the coronaviruses is translated from ORF1 to yield polyproteins that are proteolytically processed into intermediate and mature nonstructural proteins (nsps). 2019-nCoV polyproteins incorporate 16 protein domains (nsps). The putative non-structural protein 2 (nsp2) of SARS-CoV plays an important role in viral transcription and replication, and is an attractive target for anti-SARS drug development.
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