Recombinant 2019-nCoV Papain-like Protease Protein (His Tag)(Active)

    • Recombinant 2019-nCoV Papain-like Protease Protein (His Tag)-Elabscience
    • Recombinant 2019-nCoV Papain-like Protease Protein (His Tag)-Elabscience
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    • Recombinant 2019-nCoV Papain-like Protease Protein (His Tag)-Elabscience
    • Recombinant 2019-nCoV Papain-like Protease Protein (His Tag)-Elabscience
    • Recombinant 2019-nCoV Papain-like Protease Protein (His Tag)-Elabscience
    • Recombinant 2019-nCoV Papain-like Protease Protein (His Tag)-Elabscience

      Catalog number:PKSR030511

      Synonyms:Papain-like Protease; PLpro; PL-PRO; pp1a; Replicase polyprotein 1a

      Size:
      • 100µg
      • 1mg
      Qty:
      - +
      Price: $720

      Lead Time: Order now, ship in 3 daysWelcome to order from local distributors.

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      Overview

      Synonyms Papain-like Protease; PLpro; PL-PRO; pp1a; Replicase polyprotein 1a
      Species virus
      Expression_host E.coli
      Sequence Glu1564-Val1880
      Accession YP_009725299.1
      Mol_Mass 36.79 kDa
      Tag N-His
      Bio_Activity Measured by its ability to cleave a fluorogenic peptide substrate, Arg-Leu-Arg-Gly-Gly-AMC (RLRGGAMC).The Specific Activity is >80pmols/min/μg

      Properties

      Purity > 90 % as determined by reducing SDS-PAGE.
      Endotoxin < 1.0 EU per µg as determined by the LAL method.
      Storage Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
      Shipping This product is provided as lyophilized powder which is shipped with ice packs.
      Formulation Lyophilized from sterile 20 mM Tris 500mM NaCl, pH 7.4.
      Reconstitution Please refer to the printed manual for detailed information.

      Background

      The coronaviral proteases, papain-like protease (PLpro) and 3C-like protease (3CLpro), are attractive antiviral drug targets because they are essential for coronaviral replication. PLpro has the additional function of stripping ubiquitin and ISG15 from host-cell proteins to aid coronaviruses in their evasion of the host innate immune responses. Targeting PLpro with antiviral drugs may have an advantage in not only inhibiting viral replication but also inhibiting the dysregulation of signaling cascades in infected cells that may lead to cell death in surrounding, uninfected cells.

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