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Recombinant 2019-nCoV Papain-like Protease Protein (His Tag)(Active)

Uniprot : YP_009725299.1

Cat.No.:PKSR030511
Expression host: E.coli

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100µg

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Description

Synonyms	Papain-like Protease; PLpro; PL-PRO; pp1a; Replicase polyprotein 1a
Species	virus
Expression_host	E.coli
Sequence	Glu1564-Val1880
Accession	YP_009725299.1
Mol_Mass	36.79 kDa
Tag	N-His
Bio_Activity	Measured by its ability to cleave a fluorogenic peptide substrate, Arg-Leu-Arg-Gly-Gly-AMC (RLRGGAMC).The Specific Activity is >80pmols/min/μg

Properties

Purity	> 90 % as determined by reducing SDS-PAGE.
Endotoxin level	< 1.0 EU per µg as determined by the LAL method.
Storage	Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping	This product is provided as lyophilized powder which is shipped with ice packs.
Formulation	Lyophilized from sterile 20 mM Tris 500mM NaCl, pH 7.4.
Reconstitution	Please refer to the printed manual for detailed information.

Background

The coronaviral proteases, papain-like protease (PLpro) and 3C-like protease (3CLpro), are attractive antiviral drug targets because they are essential for coronaviral replication. PLpro has the additional function of stripping ubiquitin and ISG15 from host-cell proteins to aid coronaviruses in their evasion of the host innate immune responses. Targeting PLpro with antiviral drugs may have an advantage in not only inhibiting viral replication but also inhibiting the dysregulation of signaling cascades in infected cells that may lead to cell death in surrounding, uninfected cells.

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