Recombinant 2019-nCoV S1 Protein (His Tag)(D614G)(Active)

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      Catalog number:PKSR030540

      Synonyms:S1 protein; 2019-nCoV S1 protein; coronavirus S1 Protein; cov S1 Protein

      Size:
      • 1mg
      Qty:
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      Price: $3300

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      Overview

      Synonyms S1 protein; 2019-nCoV S1 protein; coronavirus S1 Protein; cov S1 Protein
      Species virus
      Expression_host Human Cells
      Sequence Gln14-Arg685(D614G)
      Accession QHD43416.1
      Mol_Mass 76.6kDa
      AP_Mol_Mass 100-130kDa
      Tag C-10His
      Bio_Activity Immobilized Recombinant Human ACE-2 Protein (Fc Tag)(Active)(Cat#PKSR030492) at 5μg/ml (100 μl/well) can bind Recombinant 2019-nCoV S1 Protein (His Tag)(D614G)(Active)(Cat#PKSR030540).The ED50 of PKSR030540 is 1.43 μg/ml.

      Properties

      Purity > 95 % as determined by reducing SDS-PAGE.
      Endotoxin < 1.0 EU per µg as determined by the LAL method.
      Storage Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
      Shipping This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs.Upon receipt; store it immediately at<-20°C.
      Formulation Supplied as a 0.2 μM filtered solution of PBS, pH 7.4.

      Background

      The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. Most notable is severe acute respiratory syndrome (SARS). The severe acute respiratory syndrome-coronavirus (SARS-CoV) spike (S) glycoprotein alone can mediate the membrane fusion required for virus entry and cell fusion. It is also a major immunogen and a target for entry inhibitors. It's been reported that 2019-nCoV can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.
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