Recombinant 2019-nCoV Spike Protein (RBD-SD1, His Tag)(Active)

    • Recombinant Rat REG4 Protein (His Tag)-Elabscience
    • Recombinant 2019-nCoV Spike Protein (RBD-SD1, His Tag)-Elabscience
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    • Recombinant Rat REG4 Protein (His Tag)-Elabscience
    • Recombinant 2019-nCoV Spike Protein (RBD-SD1, His Tag)-Elabscience
    • Recombinant Rat REG4 Protein (His Tag)-Elabscience
    • Recombinant 2019-nCoV Spike Protein (RBD-SD1, His Tag)-Elabscience

      Catalog number:PKSR030477

      Synonyms:2019-nCov RBD Protein; 2019-nCoV S RBD Protein

      Size:
      • 50µg
      • 1mg
      Qty:
      - +
      Price: $253

      Lead Time: Order now, ship in 3 daysWelcome to order from local distributors.

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      Overview

      Synonyms 2019-nCov RBD Protein; 2019-nCoV S RBD Protein
      Species Virus
      Expression_host Human Cells
      Sequence Arg319-Ser591
      Accession QHD43416.1
      Mol_Mass 31.4 kDa
      AP_Mol_Mass 35-43 kDa
      Tag C-6His
      Bio_Activity 1.Immobilized Recombinant 2019-nCoV Spike Protein (RBD-SD1, His Tag) (Cat#PKSR030477) at 5μg/ml (100 μl/well) can bind Recombinant Human ACE-2 Protein (Fc Tag)(Cat#PKSR030492).The ED50 of PKSR030492 is 76 ng/ml. 2.Immobilized Recombinant 2019-nCoV Spike Protein (RBD-SD1, His Tag) (Cat#PKSR030477) at 5μg/ml (100 μl/well) can bind SARS-COV-2 Spike S1 Monoclonal Antibody (Cat#E-AB-V1005).The ED50 of E-AB-V1005 is 2.2 ng/ml.

      Properties

      Purity > 95 % as determined by reducing SDS-PAGE.
      Endotoxin < 1.0 EU per µg as determined by the LAL method.
      Storage Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
      Shipping This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs.Upon receipt; store it immediately at<-20°C.
      Formulation Supplied as a 0.2 μM filtered solution of PBS, pH 7.4.
      Reconstitution Please refer to the printed manual for detailed information.

      Background

      Protein S (PROS1) is glycoprotein and expressed in many cell types supporting its reported involvement in multiple biological processes that include coagulation, apoptosis, cancer development and progression, and the innate immune response. Known receptors bind S1 are ACE2, angiotensin-converting enzyme 2, DPP4, CEACAM etc.. The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. Most notable is severe acute respiratory syndrome (SARS). The severe acute respiratory syndrome-coronavirus (SARS-CoV) spike (S) glycoprotein alone can mediate the membrane fusion required for virus entry and cell fusion. It is also a major immunogen and a target for entry inhibitors. It's been reported that 2019-nCoV can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.

      Image

      1.Immobilized Recombinant 2019-nCoV Spike Protein (RBD-SD1, His Tag) (Cat#PKSR030477) at 5μg/ml (100 μl/well) can bind Recombinant Human ACE-2 Protein (Fc Tag)(Cat#PKSR030492).The ED50 of PKSR030492 is 76 ng/ml.

      2.Immobilized Recombinant 2019-nCoV Spike Protein (RBD-SD1, His Tag) (Cat#PKSR030477) at 5μg/ml (100 μl/well) can bind SARS-COV-2 Spike S1 Monoclonal Antibody (Cat#E-AB-V1001).The ED50 of E-AB-V1001 is 2.2 ng/ml.

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